Linked Life Data

16697054

Source:http://linkedlifedata.com/resource/pubmed/id/16697054

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2006-6-13
pubmed:abstractText
DNA-damaging agents have a central role in non-surgical cancer treatment. The balance between DNA damage and repair determines the final therapeutic consequences. An elevated DNA-repair capacity in tumor cells leads to drug or radiation resistance and severely limits the efficacy of these agents. Interference with DNA repair has emerged as an important approach in combination therapy against cancer. Anticancer targets in DNA-repair systems have emerged, against which several small-molecule compounds are currently undergoing clinical trials.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/2-morpholin-4-yl-6-thianthren-1-yl-p..., http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins, http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm, http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Guanine, http://linkedlifedata.com/resource/pubmed/chemical/Morpholines, http://linkedlifedata.com/resource/pubmed/chemical/NU 1025, http://linkedlifedata.com/resource/pubmed/chemical/O(6)-Methylguanine-DNA..., http://linkedlifedata.com/resource/pubmed/chemical/O(6)-benzylguanine, http://linkedlifedata.com/resource/pubmed/chemical/Poly(ADP-ribose) Polymerases, http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Pyrones, http://linkedlifedata.com/resource/pubmed/chemical/Quinazolines, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins, http://linkedlifedata.com/resource/pubmed/chemical/ataxia telangiectasia mutated...
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0165-6147
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
338-44
pubmed:dateRevised
2011-11-2
pubmed:meshHeading
pubmed-meshheading:16697054-Animals, pubmed-meshheading:16697054-Antineoplastic Agents, pubmed-meshheading:16697054-Cell Cycle Proteins, pubmed-meshheading:16697054-DNA, Neoplasm, pubmed-meshheading:16697054-DNA Damage, pubmed-meshheading:16697054-DNA Repair, pubmed-meshheading:16697054-DNA-Binding Proteins, pubmed-meshheading:16697054-Drug Resistance, Neoplasm, pubmed-meshheading:16697054-Guanine, pubmed-meshheading:16697054-Humans, pubmed-meshheading:16697054-Morpholines, pubmed-meshheading:16697054-Neoplasms, pubmed-meshheading:16697054-O(6)-Methylguanine-DNA Methyltransferase, pubmed-meshheading:16697054-Poly(ADP-ribose) Polymerases, pubmed-meshheading:16697054-Protein-Serine-Threonine Kinases, pubmed-meshheading:16697054-Pyrones, pubmed-meshheading:16697054-Quinazolines, pubmed-meshheading:16697054-Signal Transduction, pubmed-meshheading:16697054-Tumor Suppressor Proteins
pubmed:year
2006
pubmed:articleTitle
Emerging cancer therapeutic opportunities target DNA-repair systems.
pubmed:affiliation
Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China. jding@mail.shcnc.ac.cn
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't