| pubmed-article:16696938 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16696938 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:16696938 | lifeskim:mentions | umls-concept:C0001527 | lld:lifeskim |
| pubmed-article:16696938 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:16696938 | lifeskim:mentions | umls-concept:C1415900 | lld:lifeskim |
| pubmed-article:16696938 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:16696938 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:16696938 | pubmed:dateCreated | 2006-6-1 | lld:pubmed |
| pubmed-article:16696938 | pubmed:abstractText | Interferon alpha (IFN-alpha) is produced in response to viral infections and used clinically in the therapy of a variety of cancers and viral infections. IFN-alpha treatment is often associated with severe weight reduction. To elucidate the mechanism of IFN-associated weight loss, we studied its effect on adipocytes in vitro and in vivo. Diet-induced obese (DIO) C57BL/6 mice were treated continuously for 8 days with human IFN-alpha A/D (100 U/g body weight) or with vehicle alone. The body weight and adipose cell size of IFN-alpha A/D-treated DIO mice were significantly lower (P<0.05 and P<0.001, respectively) as compared with those of control DIO mice. PI3K and Bcl-2 were down-regulated whereas Bax expression was elevated in adipose tissue following IFN treatment as compared to adipose tissue of control DIO mice. Treatment of differentiated 3T3-F442A adipocytes with IFN-alpha A/D (250 U/ml, 36 h) significantly increased the number of apoptotic cells from 15.8% in control cells to 56+/-6%. In conclusion, weight loss following IFN-alpha therapy is due at least in part to increased apoptosis of adipocytes. | lld:pubmed |
| pubmed-article:16696938 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16696938 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16696938 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16696938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16696938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16696938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16696938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16696938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16696938 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16696938 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16696938 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:16696938 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:16696938 | pubmed:author | pubmed-author:RubinsteinMen... | lld:pubmed |
| pubmed-article:16696938 | pubmed:author | pubmed-author:BirkRuth ZRZ | lld:pubmed |
| pubmed-article:16696938 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16696938 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:16696938 | pubmed:volume | 345 | lld:pubmed |
| pubmed-article:16696938 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16696938 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16696938 | pubmed:pagination | 669-74 | lld:pubmed |
| pubmed-article:16696938 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:16696938 | pubmed:meshHeading | pubmed-meshheading:16696938... | lld:pubmed |
| pubmed-article:16696938 | pubmed:meshHeading | pubmed-meshheading:16696938... | lld:pubmed |
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| pubmed-article:16696938 | pubmed:meshHeading | pubmed-meshheading:16696938... | lld:pubmed |
| pubmed-article:16696938 | pubmed:meshHeading | pubmed-meshheading:16696938... | lld:pubmed |
| pubmed-article:16696938 | pubmed:meshHeading | pubmed-meshheading:16696938... | lld:pubmed |
| pubmed-article:16696938 | pubmed:meshHeading | pubmed-meshheading:16696938... | lld:pubmed |
| pubmed-article:16696938 | pubmed:meshHeading | pubmed-meshheading:16696938... | lld:pubmed |
| pubmed-article:16696938 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16696938 | pubmed:articleTitle | IFN-alpha induces apoptosis of adipose tissue cells. | lld:pubmed |
| pubmed-article:16696938 | pubmed:affiliation | National Institute of Biotechnology, Ben-Gurion University, Beer-Sheba 84105, Israel. rbirk@bgu.ac.il | lld:pubmed |
| pubmed-article:16696938 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16696938 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:16696938 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
