|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0002520,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0041221,
umls-concept:C0041917,
umls-concept:C0205314,
umls-concept:C0207199,
umls-concept:C0220781,
umls-concept:C0220825,
umls-concept:C0301869,
umls-concept:C0679622,
umls-concept:C1707689,
umls-concept:C1883254
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|
pubmed:issue |
14
|
|
pubmed:dateCreated |
2006-6-5
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|
pubmed:abstractText |
Potential inhibitors of the Trypanosoma cruzi dUTP nucleotidohydrolase were docked into the enzyme using the program FlexX. Compounds that docked selectively were then selected and synthesized using solid phase methodology, giving rise to a novel library of amino acid uracil acetamide compounds which were evaluated for enzyme inhibition and anti-parasitic activity.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
16
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3809-12
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:16677813-Acetamides,
pubmed-meshheading:16677813-Amino Acids,
pubmed-meshheading:16677813-Animals,
pubmed-meshheading:16677813-Chagas Disease,
pubmed-meshheading:16677813-Drug Design,
pubmed-meshheading:16677813-Enzyme Inhibitors,
pubmed-meshheading:16677813-Inhibitory Concentration 50,
pubmed-meshheading:16677813-Models, Chemical,
pubmed-meshheading:16677813-Pyrophosphatases,
pubmed-meshheading:16677813-Trypanocidal Agents,
pubmed-meshheading:16677813-Trypanosoma cruzi,
pubmed-meshheading:16677813-Uracil
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase.
|
|
pubmed:affiliation |
Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Evaluation Studies
|
