Source:http://linkedlifedata.com/resource/pubmed/id/16677761
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2006-5-24
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| pubmed:abstractText |
The trigeminovascular system is involved in migraine. Efficacy of Botulinum Toxin type A (BoNT-A) in migraine has been investigated in clinical studies but the mechanism of action remains unexplored. It is hypothesized that BoNT-A inhibits peripheral sensitization of nociceptive fibers and indirectly reduces central sensitization. We examined the effect of intramuscular injection of BoNT-A on an experimental human model of trigeminal sensitization induced by intradermal capsaicin injection to the forehead. BoNT-A (BOTOX) or saline was injected intramuscularly in precranial, neck and shoulder muscles to 32 healthy male volunteers in a double blind-randomized manner. Intradermally capsaicin-induced pain, flare and secondary hyperalgesia were obtained before and 1, 4 and 8 weeks after the above treatments. A significant suppressive effect of BoNT-A on pain, flare and hyperalgesia area was observed. The pain intensity area was significantly smaller in BoNT-A group (9.16+/-0.83 cm x s) compared to saline group (15.41+/-0.83cm x s) (P=0.011). The flare area was also reduced significantly in BoNT-A group (29.81+/-0.69 cm2) compared to saline group (39.71+/-0.69 cm2) (P<0.001). Similarly, the mean area of secondary hyperalgesia was significantly smaller in BoNT-A group (4.25+/-0.91 cm2) compared to saline group (7.03+/-0.91 cm2) (P=0.040). Post hoc analysis showed significant differences across the trials with a remarkable suppression effect of BoNT-A on capsaicin-induced sensory and vasomotor reactions as early as week1 (P<0.001). BoNT-A presented suppressive effects on the trigeminal/cervical nociceptive system activated by intradermal injection of capsaicin to the forehead. The effects are suggested to be caused by a local peripheral effect of BoNT-A on cutaneous nociceptors.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
1872-6623
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
122
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
315-25
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:16677761-Adult,
pubmed-meshheading:16677761-Botulinum Toxins, Type A,
pubmed-meshheading:16677761-Capsaicin,
pubmed-meshheading:16677761-Face,
pubmed-meshheading:16677761-Forehead,
pubmed-meshheading:16677761-Humans,
pubmed-meshheading:16677761-Hyperalgesia,
pubmed-meshheading:16677761-Injections, Intradermal,
pubmed-meshheading:16677761-Male,
pubmed-meshheading:16677761-Pain,
pubmed-meshheading:16677761-Pain Measurement,
pubmed-meshheading:16677761-Pain Threshold,
pubmed-meshheading:16677761-Pressure,
pubmed-meshheading:16677761-Regional Blood Flow,
pubmed-meshheading:16677761-Skin Temperature,
pubmed-meshheading:16677761-Trigeminal Nerve,
pubmed-meshheading:16677761-Urticaria
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| pubmed:year |
2006
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| pubmed:articleTitle |
The effects of Botulinum Toxin type A on capsaicin-evoked pain, flare, and secondary hyperalgesia in an experimental human model of trigeminal sensitization.
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| pubmed:affiliation |
Laboratory for Experimental Pain Research, Centre for Sensory-Motor Interaction (SMI), Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7D-3, DK-9220 Aalborg, Denmark.
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| pubmed:publicationType |
Journal Article
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