Linked Life Data

1665630

Source:http://linkedlifedata.com/resource/pubmed/id/1665630

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1992-4-3
pubmed:abstractText
The investigations were carried out to evaluate potential side effects of a prophylaxis with high doses of vitamin D3 and vitamin D metabolites in parturient paresis. For this reason, 10(7) IU vitamin D3 (= 250 mg), 4 mg 25-OHD3 or 420 micrograms 1 alpha-OHD3 were applied to non-gravid dairy cows at the end of lactation. The application was repeated 3 times at one week intervals and the changes of the mineral concentration and 25-OHD were measured in the plasma. The pathomorphological changes in the cardio-vascular system and other organs were examined macro- and microscopically. The application of vitamin D3 and 25-OHD3 led to an immediate and continuous increase of the 25-OHD concentration in the plasma. On the other hand, administration of 1 alpha-OHD3 resulted in a decrease of the 25-OHD level. After the application of vitamin D3 and 1 alpha-OHD3, the Ca and Pi concentration increased significantly. After 25-OHD3, the Ca concentration decreased below the initial level in the second week. The administration of all 3 compounds led to a significant decrease of the Mg concentration after the first injection. The administration of vitamin D3 and 1 alpha-OHD3 resulted in a significantly more pronounced calcinosis of inner organs while after the application of 25-OHD3 only occasionally calcium deposits were observed in the vascular system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0514-7158
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
763-9
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
The effects of intramuscularly administered vitamin D3, 25- and 1 alpha-hydroxycholecalciferol in cows on plasma mineral content, plasma 25-hydroxycholecalciferol and on mineral deposits in soft tissues.
pubmed:affiliation
Veterinary Practice Kamin, Children's Hospital, Friedrich Schiller University, Jena.
pubmed:publicationType
Journal Article