Linked Life Data

16642713

Source:http://linkedlifedata.com/resource/pubmed/id/16642713

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2006-4-28
pubmed:abstractText
The combination of medetomidine-zolazepam-tiletamine with subsequent antagonism by atipamezole was evaluated for reversible anaesthesia of free-ranging lions (Panthera leo). Twenty-one anaesthetic events of 17 free-ranging lions (5 males and 12 females, body weight 105-211 kg) were studied in Zimbabwe. Medetomidine at 0.027-0.055 mg/kg (total dose 4-11 mg) and zolazepam-tiletamine at 0.38-1.32 mg/kg (total dose 50-275 mg) were administered i.m. by dart injection. The doses were gradually decreased to improve recovery. Respiratory and heart rates, rectal temperature and relative haemoglobin oxygen saturation (SpO2) were recorded every 15 min. Arterial blood samples were collected from 5 lions for analysis of blood gases and acid-base status. For anaesthetic reversal, atipamezole was administered i.m. at 2.5 or 5 times the medetomidine dose. Induction was smooth and all lions were anaesthetised with good muscle relaxation within 3.4-9.5 min after darting. The predictable working time was a minimum of 1 h and no additional drug doses were needed. Respiratory and heart rates and SpO2 were stable throughout anaesthesia, whereas rectal temperature changed significantly over time. Atipamezole at 2.5 times the medetomidine dose was sufficient for reversal and recoveries were smooth and calm in all lions independent of the atipamezole dose. First sign of recovery was observed 3-27 min after reversal. The animals were up walking 8-26 min after reversal when zolazepam-tiletamine doses < 1 mg/kg were used. In practice, a total dose of 6 mg medetomidine and 80 mg zolazepam-tiletamine and reversal with 15 mg atipamezole can be used for either sex of an adult or subadult lion. The drugs and doses used in this study provided a reliable, safe and reversible anaesthesia protocol for free-ranging lions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1019-9128
pubmed:author
pubmed:issnType
Print
pubmed:volume
76
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
187-92
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:16642713-Adrenergic alpha-Antagonists, pubmed-meshheading:16642713-Anesthesia, pubmed-meshheading:16642713-Anesthetics, Combined, pubmed-meshheading:16642713-Anesthetics, Dissociative, pubmed-meshheading:16642713-Animals, pubmed-meshheading:16642713-Animals, Wild, pubmed-meshheading:16642713-Blood Pressure, pubmed-meshheading:16642713-Body Temperature, pubmed-meshheading:16642713-Dose-Response Relationship, Drug, pubmed-meshheading:16642713-Female, pubmed-meshheading:16642713-Heart Rate, pubmed-meshheading:16642713-Hypnotics and Sedatives, pubmed-meshheading:16642713-Imidazoles, pubmed-meshheading:16642713-Injections, Intramuscular, pubmed-meshheading:16642713-Lions, pubmed-meshheading:16642713-Male, pubmed-meshheading:16642713-Medetomidine, pubmed-meshheading:16642713-Respiration, pubmed-meshheading:16642713-Tiletamine, pubmed-meshheading:16642713-Time Factors, pubmed-meshheading:16642713-Zimbabwe, pubmed-meshheading:16642713-Zolazepam
pubmed:year
2005
pubmed:articleTitle
Reversible anaesthesia of free-ranging lions (Panthera leo) in Zimbabwe.
pubmed:affiliation
Section of Anaesthesiology and Emergency and Critical Care, Department of Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, Swedish University of Agricultural Sciences, PO Box 7018, SE-750 07 Uppsala, Sweden. asa_fahlman@hotmail.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't