Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2006-5-17
pubmed:abstractText
The pathogenesis of malarial anemia is multifactorial, and the mechanisms responsible for its high mortality are poorly understood. Studies indicate that host mediators produced during malaria infection may suppress erythroid progenitor development (Miller, K.L., J.C. Schooley, K.L. Smith, B. Kullgren, L.J. Mahlmann, and P.H. Silverman. 1989. Exp. Hematol. 17:379-385; Yap, G.S., and M.M. Stevenson. 1991. Ann. NY Acad. Sci. 628:279-281). We describe an intrinsic role for macrophage migration inhibitory factor (MIF) in the development of the anemic complications and bone marrow suppression that are associated with malaria infection. At concentrations found in the circulation of malaria-infected patients, MIF suppressed erythropoietin-dependent erythroid colony formation. MIF synergized with tumor necrosis factor and gamma interferon, which are known antagonists of hematopoiesis, even when these cytokines were present in subinhibitory concentrations. MIF inhibited erythroid differentiation and hemoglobin production, and it antagonized the pattern of mitogen-activated protein kinase phosphorylation that normally occurs during erythroid progenitor differentiation. Infection of MIF knockout mice with Plasmodium chabaudi resulted in less severe anemia, improved erythroid progenitor development, and increased survival compared with wild-type controls. We also found that human mononuclear cells carrying highly expressed MIF alleles produced more MIF when stimulated with the malarial product hemozoin compared with cells carrying low expression MIF alleles. These data suggest that polymorphisms at the MIF locus may influence the levels of MIF produced in the innate response to malaria infection and the likelihood of anemic complications.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-10364264, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-10466119, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-10474636, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-10479160, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-10655104, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-10666228, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-10722628, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-10733512, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-10942626, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-10950804, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-11397892, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-11687458, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-11756671, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-11780066, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-11832955, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-12070782, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-12224573, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-12355488, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-12402212, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-12484628, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-12581192, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-12967673, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-1310133, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-1391934, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-14502271, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-14739226, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-14744558, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-14962818, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-14965485, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-14978116, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-15039754, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-15582527, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-15630134, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-1582489, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-15982354, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-16077028, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-16186482, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-2069308, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-2257320, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-2651136, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-3801660, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-3902119, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-4609912, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-4899445, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-6166564, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-64982, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-7052195, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-7485716, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-7583361, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-7659164, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-7947826, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-8063391, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-8195715, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-8300197, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-8600766, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-9055860, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-9136961, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-9395308, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-9414641, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-9430513, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-9484971, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-9598460, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-9765250, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-9797826, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-9886304, http://linkedlifedata.com/resource/pubmed/commentcorrection/16636133-9892616
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-1007
pubmed:author
More...