Source:http://linkedlifedata.com/resource/pubmed/id/16626979
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
2006-8-7
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pubmed:abstractText |
Chondrocytes in articular cartilage are surrounded by a narrow pericellular matrix (PCM), which together with the enclosed cell(s) are termed the "chondron". Although the precise function of this tissue region is unknown, previous studies provide indirect evidence that the PCM plays an important role in governing the local mechanical environment of chondrocytes. In particular, theoretical models of the chondron under mechanical loading suggest that the shape, size, and biomechanical properties of the PCM significantly influence the stress-strain and fluid flow environment of the cell. The goal of this study was to quantify the three-dimensional morphology of chondron in situ using en bloc immunolabeling of type VI collagen coupled with fluorescence confocal microscopy.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1063-4584
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
889-97
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:16626979-Animals,
pubmed-meshheading:16626979-Cartilage, Articular,
pubmed-meshheading:16626979-Chondrocytes,
pubmed-meshheading:16626979-Collagen Type VI,
pubmed-meshheading:16626979-Extracellular Matrix,
pubmed-meshheading:16626979-Image Processing, Computer-Assisted,
pubmed-meshheading:16626979-Imaging, Three-Dimensional,
pubmed-meshheading:16626979-Knee Joint,
pubmed-meshheading:16626979-Microscopy, Confocal,
pubmed-meshheading:16626979-Microscopy, Electron, Transmission,
pubmed-meshheading:16626979-Swine,
pubmed-meshheading:16626979-Tissue Preservation
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pubmed:year |
2006
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pubmed:articleTitle |
Zonal variations in the three-dimensional morphology of the chondron measured in situ using confocal microscopy.
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pubmed:affiliation |
Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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