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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2006-7-4
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pubmed:abstractText |
Individuals homozygous for the thermolabile variant (677TT) of methylenetetrahydrofolate reductase exhibit reduced folate status as evidenced by a drop in the biomarker red cell folate (RCF) compared to those who carry at least one 677C allele. We now report that a different polymorphism in the same enzyme, namely 1298A>C, is associated with increased RCF levels. Thus, these two common polymorphisms change a metabolic phenotype in opposite directions suggesting that their cancer protective associations are by different mechanisms.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1096-7192
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
290-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16621645-Biological Markers,
pubmed-meshheading:16621645-Erythrocytes,
pubmed-meshheading:16621645-Female,
pubmed-meshheading:16621645-Folic Acid,
pubmed-meshheading:16621645-Genotype,
pubmed-meshheading:16621645-Homocysteine,
pubmed-meshheading:16621645-Homozygote,
pubmed-meshheading:16621645-Humans,
pubmed-meshheading:16621645-Methylenetetrahydrofolate Reductase (NADPH2),
pubmed-meshheading:16621645-Polymorphism, Single Nucleotide,
pubmed-meshheading:16621645-Pregnancy,
pubmed-meshheading:16621645-Prospective Studies
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pubmed:year |
2006
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pubmed:articleTitle |
The MTHFR 1298CC and 677TT genotypes have opposite associations with red cell folate levels.
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pubmed:affiliation |
School of Biochemistry and Immunology, Trinity College Dublin, Ireland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Intramural
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