16616489

Source:http://linkedlifedata.com/resource/pubmed/id/16616489

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0220781, umls-concept:C0443286, umls-concept:C1152568, umls-concept:C1883254, umls-concept:C1948027
pubmed:issue	12
pubmed:dateCreated	2006-5-8
pubmed:abstractText	A new series of 2-aryl-substituted purine derivatives has been synthesized by Suzuki Pd(0) coupling reactions. Moderate in vitro inhibitory activity against Cdk1 and Cdk5 was observed. These compounds are inactive against GSK3.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/CDC2 Protein Kinase, http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase 5, http://linkedlifedata.com/resource/pubmed/chemical/Glycogen Synthase Kinase 3, http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Purines, http://linkedlifedata.com/resource/pubmed/chemical/purine
pubmed:status	MEDLINE
pubmed:month	Jun
pubmed:issn	0960-894X
pubmed:author	pubmed-author:GriersonDavid SDS, pubmed-author:LegraverendMichelM, pubmed-author:LozachOlivierO, pubmed-author:MeijerLaurentL, pubmed-author:PiguelSandrineS, pubmed-author:VandrommeLucieL
pubmed:issnType	Print
pubmed:day	15
pubmed:volume	16
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	3144-6
pubmed:dateRevised	2009-11-19
pubmed:meshHeading	pubmed-meshheading:16616489-CDC2 Protein Kinase, pubmed-meshheading:16616489-Cyclin-Dependent Kinase 5, pubmed-meshheading:16616489-Glycogen Synthase Kinase 3, pubmed-meshheading:16616489-Molecular Structure, pubmed-meshheading:16616489-Protein Kinase Inhibitors, pubmed-meshheading:16616489-Purines
pubmed:year	2006
pubmed:articleTitle	Suzuki-type Pd(0) coupling reactions in the synthesis of 2-arylpurines as Cdk inhibitors.
pubmed:affiliation	UMR 176 CNRS-Institut Curie, Institut Curie Section de Recherche, Bât. 110, Centre Universitaire, 91405 Orsay, France.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't