|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2006-5-8
|
|
pubmed:abstractText |
We analysed the contribution of the lymphoid protein tyrosine phosphatase (LYP) Arg620Trp variant (which corresponds to the PTPN22 C1858T polymorphism) to the emergence of beta-cell-specific humoral autoimmunity and progression to type 1 diabetes in man. We also explored the heterogeneity in the disease-predisposing effect of this polymorphism in relation to known disease loci, sex and age at disease onset.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Arginine,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamate Decarboxylase,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQ Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/PTPN22 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatase...,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatase...,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Tryptophan
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0012-186X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
49
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1198-208
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:16614815-Adolescent,
pubmed-meshheading:16614815-Amino Acid Substitution,
pubmed-meshheading:16614815-Arginine,
pubmed-meshheading:16614815-Autoantibodies,
pubmed-meshheading:16614815-Child,
pubmed-meshheading:16614815-Child, Preschool,
pubmed-meshheading:16614815-Diabetes Mellitus, Type 1,
pubmed-meshheading:16614815-Disease Progression,
pubmed-meshheading:16614815-Female,
pubmed-meshheading:16614815-Genetic Variation,
pubmed-meshheading:16614815-Glutamate Decarboxylase,
pubmed-meshheading:16614815-HLA-DQ Antigens,
pubmed-meshheading:16614815-Humans,
pubmed-meshheading:16614815-Infant,
pubmed-meshheading:16614815-Infant, Newborn,
pubmed-meshheading:16614815-Insulin Antibodies,
pubmed-meshheading:16614815-Male,
pubmed-meshheading:16614815-Mass Screening,
pubmed-meshheading:16614815-Nuclear Family,
pubmed-meshheading:16614815-Protein Tyrosine Phosphatase, Non-Receptor Type 1,
pubmed-meshheading:16614815-Protein Tyrosine Phosphatase, Non-Receptor Type 22,
pubmed-meshheading:16614815-Protein Tyrosine Phosphatases,
pubmed-meshheading:16614815-Sex Characteristics,
pubmed-meshheading:16614815-Tryptophan
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Lymphoid tyrosine phosphatase (LYP/PTPN22) Arg620Trp variant regulates insulin autoimmunity and progression to type 1 diabetes.
|
|
pubmed:affiliation |
JDRF Centre for Prevention of Type 1 Diabetes in Finland, Turku, Finland. robert.hermann@utu.fi
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
