Source:http://linkedlifedata.com/resource/pubmed/id/16596172
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2006-4-5
|
| pubmed:abstractText |
N-cadherin signaling has recently been implicated in the progression of certain epithelial tumors by promoting invasion and dissemination of cancer cells. N-cadherin has also been reported to exert an anti-apoptotic effect. In this study, we attempted to evaluate the participation of this adhesion molecule in the progression of human hepatocellular carcinomas (HCCs) by analyzing its anti-apoptotic signaling as well as its prognostic implication in HCC patients. N-cadherin was found to be expressed in human HCCs. We established a stable human HCC cell line expressing a truncated N-cadherin, NCaddeltaC, with a dominant-negative action. NCaddeltaC-expressing cells were more susceptible to bile acid-induced apoptosis than control cells. N-cadherin was found to complex with procaspase-8, and this association was diminished in NCaddeltaC-expressing cells, leading to enhanced procaspase-8 recruitment to death-inducing signaling complex following bile acid treatment. A clinicopathological analysis in patients who had undergone surgical resection for HCC revealed that tumoral N-cadherin up-regulation was significantly related to poor recurrence-free and overall survival. Our findings implicate N-cadherin signaling as contributing to HCC progression by exerting anti-apoptotic effects. Thus, we suggest that the selective interruption of this signaling may have therapeutic potential.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bile Acids and Salts,
http://linkedlifedata.com/resource/pubmed/chemical/CASP8 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cadherins,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 8,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
1021-335X
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| pubmed:author |
pubmed-author:GwakGeum-YounGY,
pubmed-author:JangJa JuneJJ,
pubmed-author:LeeHyo-SukHS,
pubmed-author:LeeKyoung BunKB,
pubmed-author:LeeSoo-MiSM,
pubmed-author:LeeSung-HeeSH,
pubmed-author:ParkSu CheolSC,
pubmed-author:ShinChan SooCS,
pubmed-author:SuhKyung-SukKS,
pubmed-author:YoonJung-HwanJH,
pubmed-author:YuSu JongSJ
|
| pubmed:issnType |
Print
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1117-23
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:16596172-Apoptosis,
pubmed-meshheading:16596172-Bile Acids and Salts,
pubmed-meshheading:16596172-Cadherins,
pubmed-meshheading:16596172-Carcinoma, Hepatocellular,
pubmed-meshheading:16596172-Caspase 8,
pubmed-meshheading:16596172-Caspases,
pubmed-meshheading:16596172-Disease Progression,
pubmed-meshheading:16596172-Female,
pubmed-meshheading:16596172-Genes, Dominant,
pubmed-meshheading:16596172-Humans,
pubmed-meshheading:16596172-Liver Neoplasms,
pubmed-meshheading:16596172-Male,
pubmed-meshheading:16596172-Middle Aged,
pubmed-meshheading:16596172-Neoplasm Invasiveness,
pubmed-meshheading:16596172-Neoplasm Recurrence, Local,
pubmed-meshheading:16596172-Neoplasm Staging,
pubmed-meshheading:16596172-Prognosis,
pubmed-meshheading:16596172-Retrospective Studies,
pubmed-meshheading:16596172-Tumor Markers, Biological
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Anti-apoptotic N-cadherin signaling and its prognostic implication in human hepatocellular carcinomas.
|
| pubmed:affiliation |
Department of Internal Medicine, Seoul National University College of Medicine, Chongno-gu, Seoul, Republic of Korea.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|