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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1991-12-31
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pubmed:abstractText |
Infection with human T-cell leukemia virus type-I (HTLV-1) is associated with a low incidence of morbidity in the form of adult T-cell leukemia as well as neurologic disease, including tropical spastic paraparesis/HTLV-I-associated myelopathy, suggesting that there are other important factors which determine outcome of infection. HTLV-I and the human herpesvirus, cytomegalovirus (HCMV), have both been shown to infect OKT4+ T lymphocytes in vitro as well as in vivo. We investigated the effects of expression of HCMV IE-2 protein(s) on the HTLV-I long terminal repeat (LTR) containing the promoter elements in T-cell lines and primary lymphocytes. A consistent repressive effect was observed on HTLV-I LTR-driven chloramphenicol acetyl transferase activity after cotransfection with the HCMV IE-2 gene region, both in HTLV-I-producing cell lines as well as in uninfected primary peripheral blood lymphocytes and cloned lymphocyte lines. This repressive effect on the HTLV-I LTR by the HCMV IE-2 gene product(s) represent a unique interaction between two viruses capable of infecting the same target cell in vivo. Such an interaction may have important implications for disease expression associated with HTLV-I infection.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/IE2 protein, Cytomegalovirus,
http://linkedlifedata.com/resource/pubmed/chemical/Immediate-Early Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/UL115 protein, Human herpesvirus 5,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Envelope Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/glycoprotein H, Cytomegalovirus,
http://linkedlifedata.com/resource/pubmed/chemical/glycoprotein H, Human...,
http://linkedlifedata.com/resource/pubmed/chemical/glycoprotein O, cytomegalovirus
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0006-4971
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2956-61
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:1659469-Base Sequence,
pubmed-meshheading:1659469-Cytomegalovirus,
pubmed-meshheading:1659469-DNA Mutational Analysis,
pubmed-meshheading:1659469-Gene Expression Regulation, Viral,
pubmed-meshheading:1659469-Human T-lymphotropic virus 1,
pubmed-meshheading:1659469-Immediate-Early Proteins,
pubmed-meshheading:1659469-Membrane Glycoproteins,
pubmed-meshheading:1659469-Molecular Sequence Data,
pubmed-meshheading:1659469-Nuclear Proteins,
pubmed-meshheading:1659469-Promoter Regions, Genetic,
pubmed-meshheading:1659469-RNA, Viral,
pubmed-meshheading:1659469-Repressor Proteins,
pubmed-meshheading:1659469-Trans-Activators,
pubmed-meshheading:1659469-Viral Envelope Proteins,
pubmed-meshheading:1659469-Viral Proteins
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pubmed:year |
1991
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pubmed:articleTitle |
The promoter of human T-cell leukemia virus type-I is repressed by the immediate-early gene region of human cytomegalovirus in primary blood lymphocytes.
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pubmed:affiliation |
Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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