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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-5-17
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pubmed:abstractText |
The clinical spectrum of leprosy is related to patients' immune responses. Non-responsiveness towards Mycobacterium leprae (ML) seems to correlate with a Th2 cytokine profile. The reason for such a polarized immune response remains unclear. The C-type lectin, DC-SIGN, expressed by subsets of dendritic cells (DCs) and macrophages, has previously been associated with Th2 responses. Here we show abundant DC-SIGN expression in lepromatous but not borderline tuberculoid leprosy, in both HIV-positive and HIV-negative patients. Moreover, we demonstrate that DC-SIGN can act as an entry receptor for ML, as it does for M. tuberculosis, through the cell wall component lipoarabinomannan. DC-SIGN is expressed on virtually all ML-containing cells, providing further evidence for its role as a receptor. DC-SIGN may therefore be induced on macrophages in lepromatous leprosy and may then contribute to mycobacterial entry into these cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media,
http://linkedlifedata.com/resource/pubmed/chemical/DC-specific ICAM-3 grabbing...,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/lipoarabinomannan
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-3417
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pubmed:author |
pubmed-author:ColemanNN,
pubmed-author:GoddardM JMJ,
pubmed-author:HernandezM OMO,
pubmed-author:HorsleyJJ,
pubmed-author:LopesU GUG,
pubmed-author:MoseleyEE,
pubmed-author:SampaioE PEP,
pubmed-author:SarnoE NEN,
pubmed-author:ShattockR JRJ,
pubmed-author:SoilleuxE JEJ,
pubmed-author:VowlerS LSL
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pubmed:copyrightInfo |
Copyright (c) 2006 Pathological Society of Great Britain and Ireland.
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pubmed:issnType |
Print
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pubmed:volume |
209
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
182-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16583355-Adult,
pubmed-meshheading:16583355-Antigens, Bacterial,
pubmed-meshheading:16583355-Cell Adhesion Molecules,
pubmed-meshheading:16583355-Cell Line,
pubmed-meshheading:16583355-Culture Media,
pubmed-meshheading:16583355-Female,
pubmed-meshheading:16583355-HIV Seronegativity,
pubmed-meshheading:16583355-HIV Seropositivity,
pubmed-meshheading:16583355-Humans,
pubmed-meshheading:16583355-Lectins, C-Type,
pubmed-meshheading:16583355-Leprosy,
pubmed-meshheading:16583355-Leprosy, Borderline,
pubmed-meshheading:16583355-Leprosy, Tuberculoid,
pubmed-meshheading:16583355-Lipopolysaccharides,
pubmed-meshheading:16583355-Macrophages,
pubmed-meshheading:16583355-Male,
pubmed-meshheading:16583355-Middle Aged,
pubmed-meshheading:16583355-Mycobacterium leprae,
pubmed-meshheading:16583355-Mycobacterium tuberculosis,
pubmed-meshheading:16583355-Receptors, Cell Surface,
pubmed-meshheading:16583355-Th2 Cells,
pubmed-meshheading:16583355-Transfection
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pubmed:year |
2006
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pubmed:articleTitle |
DC-SIGN association with the Th2 environment of lepromatous lesions: cause or effect?
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pubmed:affiliation |
Department of Histopathology, Papworth Hospital, Papworth Everard, Cambridge CB3 8RE, and Nuffield Department of Clinical Laboratory Sciences, University of Oxford, UK. E.J.Soilleux.91@cantab.net
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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