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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2006-4-26
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pubmed:abstractText |
Postnatal glutamatergic principal neuron synapses are typically presumed to express only calcium-impermeable (CI), GluR2-containing AMPARs under physiological conditions. Here, however, we demonstrate that long-term potentiation (LTP) in CA1 hippocampal pyramidal neurons causes rapid incorporation of GluR2-lacking calcium-permeable (CP)-AMPARs: CP-AMPARs are present transiently, being replaced by GluR2-containing AMPARs approximately 25 min after LTP induction. Thus, CP-AMPARs are physiologically expressed at CA1 pyramidal cell synapses during LTP, and may be required for LTP consolidation.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1097-6256
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
602-4
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pubmed:dateRevised |
2007-8-13
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pubmed:meshHeading |
pubmed-meshheading:16582904-Animals,
pubmed-meshheading:16582904-Animals, Newborn,
pubmed-meshheading:16582904-Calcium,
pubmed-meshheading:16582904-Dose-Response Relationship, Radiation,
pubmed-meshheading:16582904-Electric Stimulation,
pubmed-meshheading:16582904-Excitatory Postsynaptic Potentials,
pubmed-meshheading:16582904-Hippocampus,
pubmed-meshheading:16582904-Long-Term Potentiation,
pubmed-meshheading:16582904-Mice,
pubmed-meshheading:16582904-Nicotinic Antagonists,
pubmed-meshheading:16582904-Patch-Clamp Techniques,
pubmed-meshheading:16582904-Polyamines,
pubmed-meshheading:16582904-Pyramidal Cells,
pubmed-meshheading:16582904-Rats,
pubmed-meshheading:16582904-Receptors, AMPA,
pubmed-meshheading:16582904-Time Factors
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pubmed:year |
2006
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pubmed:articleTitle |
Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation.
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pubmed:affiliation |
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, Bristol BS8 1TD, UK.
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Intramural
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