Linked Life Data

1658087

Source:http://linkedlifedata.com/resource/pubmed/id/1658087

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-12-13
pubmed:abstractText
Recent works utilizing glycine-immunoreactivity (IR) and combined Golgi impregnation and 3H-glycine uptake autoradiography indicate that glycinergic interplexiform cells (IPC) may synapse upon cell bodies in the inner nuclear and ganglion cell layers in fish retina. This possibility was investigated with immunocytochemical techniques using presynaptic and postsynaptic markers for glycinergic neurons: a monoclonal antibody (mAb 7A) against the 93 kDa subunit of the strychnine-sensitive glycine receptor and a polyclonal antiserum against a glycine/BSA conjugate. Synaptic contacts onto the lateral and proximal surfaces of amacrine cell bodies and onto the distal surface of cells in the ganglion cell layer were identified with both probes. The contacts were rare with one contacted amacrine cell/section of 500 linear micron. Serial 1-micron sections were processed alternately for glycine and GABA antisera using postembedding techniques at the light microscopic level. Glycine-IR processes + boutons were apposed to GABA-IR cell bodies in 16 of 17 examples, indicating that the dendro-somatic contacts were onto GABA-immunoreactive amacrine cell bodies. In context of other published morphological data, we suggest that the dendro-somatic synapses were derived from glycinergic IPCs. Glycinergic IPCs receive input from GABAergic horizontal cells and, via a shunt conductance produced by the dendro-somatic contacts, may be involved in controlling the sensitivity, temporal, or spatial properties of amacrine cell responses to large field illumination.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0021-9967
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
310
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-10
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Glycinergic interplexiform cells make synaptic contact with amacrine cell bodies in goldfish retina.
pubmed:affiliation
Department of Neurobiology and Behavior, State University of New York, Stony Brook 11794-5230.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.