Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2006-6-5
pubmed:abstractText
The aim of this pilot study was to examine the relationship between clinical response, adverse effects, sertraline (SERT) plasma concentrations and the genetic polymorphism of the serotonin transporter gene-linked polymorphic region (5HTTLPR) in 2 ethnic patient groups. The study involved 45 patients in a clinical trial who received a fixed dose regimen of 50 mg SERT for one week, then a variable-dose regimen for a further 6 weeks for major depressive disorder. At weeks 1 and 6, the following assessments were completed: Hamilton Depression Rating Scale (HDRS), Clinical Global Impression (CGI), drug adverse reaction scale and measurement of plasma SERT levels. Genomic analysis for the long and short allele variants of the 5HTTLPR polymorphism was also carried out. Caucasian subjects had a higher rate of l/l genotype while Chinese subjects had higher frequencies of l/s and s/s genotypes. Comparison of the subjects with the 5HTTLPR s/s genotype and those with the l/l and l/s genotypes found no significant differences in the HDRS scores, CGI scores, response rates, adverse effects and SERT plasma concentrations at week 6.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0278-5846
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
953-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:16580768-Adult, pubmed-meshheading:16580768-Alleles, pubmed-meshheading:16580768-Antidepressive Agents, Second-Generation, pubmed-meshheading:16580768-Asian Continental Ancestry Group, pubmed-meshheading:16580768-Australia, pubmed-meshheading:16580768-China, pubmed-meshheading:16580768-DNA, pubmed-meshheading:16580768-Depressive Disorder, pubmed-meshheading:16580768-Ethnic Groups, pubmed-meshheading:16580768-European Continental Ancestry Group, pubmed-meshheading:16580768-Female, pubmed-meshheading:16580768-Gene Frequency, pubmed-meshheading:16580768-Genotype, pubmed-meshheading:16580768-Humans, pubmed-meshheading:16580768-Male, pubmed-meshheading:16580768-Middle Aged, pubmed-meshheading:16580768-Polymorphism, Genetic, pubmed-meshheading:16580768-Prospective Studies, pubmed-meshheading:16580768-Psychiatric Status Rating Scales, pubmed-meshheading:16580768-Serotonin Plasma Membrane Transport Proteins, pubmed-meshheading:16580768-Sertraline
pubmed:year
2006
pubmed:articleTitle
Serotonin transporter polymorphisms and clinical response to sertraline across ethnicities.
pubmed:affiliation
Professorial Unit, The Melbourne Clinic, University of Melbourne, Australia. cng@unimelb.edu.au
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Research Support, Non-U.S. Gov't