Linked Life Data

16569340

Source:http://linkedlifedata.com/resource/pubmed/id/16569340

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-3-29
pubmed:abstractText
Insulin-like growth factor-1 (IGF-1) is involved in regulating the Th-1/Th-2 balance, favoring the development of the Th-2 compartment which enhances fibrosis, one of the main characteristics of Chronic Lung Disease (CLD) in premature newborns. Limited data is available concerning a possible association between early epithelial lining fluid (ELF) concentrations of IGF-1 (total and free forms), IGF-binding protein-3 (IGFBP-3), beta2-microglobulin and subsequent development of CLD in preterm neonates. If neutropenic, preterm neonates are frequently treated with recombinant human granulocyte colony stimulating factor (rhG-CSF). The objective of the study was to correlate ELF concentrations of IGF-1 and beta2 microglobulin during the first week of life both in non-neutropenic and in rhGCSF-treated neutropenic preterm neonates, with subsequent development in CLD. Thirty preterm neonates with Respiratory Distress Syndrome (6 with neutropenia) were studied. Eleven out of 24 non-neutropenic preterm infants (46%) and all of the six neutropenic subjects (100%) developed CLD. With the exception of first day values, there was a clear similarity in the behaviors of assayed molecules between non-neutropenic and neutropenic patients developing CLD. Non-neutropenic patients without CLD showed significantly lower values of free IGF-1 and beta2M both on days 1 and 3. Total IGF-I and cell counts were different only on the 3rd day. Conclusions: 1) the mechanisms leading to CLD might be mediated by high levels of IGF-family molecules soon after birth 2) beta2M could be a marker of increased bronchoalveolar lavage fluid cellularity with potential inflammatory properties 3) G-CSF treatment induces an increased synthesis of IGF-1 molecules by cells recruited in the lung, with possible enhancement of the fibrogenic mechanisms.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0394-6320
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
57-66
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:16569340-Bronchoalveolar Lavage Fluid, pubmed-meshheading:16569340-Cell Count, pubmed-meshheading:16569340-Chlamydia Infections, pubmed-meshheading:16569340-Chronic Disease, pubmed-meshheading:16569340-Epithelial Cells, pubmed-meshheading:16569340-Granulocyte Colony-Stimulating Factor, pubmed-meshheading:16569340-Humans, pubmed-meshheading:16569340-Infant, Newborn, pubmed-meshheading:16569340-Infant, Premature, pubmed-meshheading:16569340-Insulin-Like Growth Factor Binding Protein 3, pubmed-meshheading:16569340-Insulin-Like Growth Factor I, pubmed-meshheading:16569340-Neutropenia, pubmed-meshheading:16569340-Pulmonary Fibrosis, pubmed-meshheading:16569340-Recombinant Proteins, pubmed-meshheading:16569340-Ureaplasma Infections, pubmed-meshheading:16569340-Ureaplasma urealyticum, pubmed-meshheading:16569340-beta 2-Microglobulin
pubmed:articleTitle
Increased levels of IGF-1 and beta2-microglobulin in epithelial lining fluid of preterm newborns developing chronic lung disease. effects of rhG-CSF.
pubmed:affiliation
Biochemistry and Clinical-Biochemistry Institute, Catholic University School of Medicine, Largo F. Vito 1, 00168 Rome, Italy. ecapoluongo@rm.unicatt.it
pubmed:publicationType
Journal Article