Linked Life Data

16563088

Source:http://linkedlifedata.com/resource/pubmed/id/16563088

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2006-3-27
pubmed:abstractText
Photolyases comprise efficient enzymes to remove the major UV-induced DNA lesions, cyclobutane pyrimidine dimers (CPDs) and 6-4 photoproducts (6-4PPs). While photolyases are present in all three kingdoms of life (i.e., bacteria, prokaryotes and eukaryotes), placental mammals appear to have lost these enzymes when they diverted from marsupials during evolution. Consequently, man and mice have to rely solely on the more complex and, for these lesions, less efficient nucleotide excision repair (NER) system. To assess the relative contribution of CPDs and 6-4PPs to the cytotoxic and genotoxic effects of the UV component of sunlight, we have recently generated a comprehensive set of transgenic mice expressing CPD and/or 6-4PP photolyases. Here, we discuss the use of photolyase transgenic mice as effective tools to study the adverse effects of UV irradiation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1479-6694
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
191-9
pubmed:dateRevised
2006-7-3
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Photolyases: capturing the light to battle skin cancer.
pubmed:affiliation
Department of Cell Biology and Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands. g.garinis@erasmusmc.nl
pubmed:publicationType
Journal Article, Review