Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-6-29
pubmed:abstractText
A subcellular extract prepared from nonencapsulated Diplococcus pneumoniae type 3 protected mice against a subsequent challenge with virulent D. pneumoniae types 1, 2, 3, and 7. Potency ratios ranged from 25 (type 3) to >1,175 (type 1). The immunity induced in mice by this preparation was best obtained by intraperitoneal inoculation followed by intravenous challenge. Mice immunized in this manner were protected up to 12 weeks and could withstand a challenge of several hundred LD(50). The protection was destroyed by treatment of the preparation with ribonuclease and was decreased by treatment with protease. The preparation consisted of 60.5% ribonucleic acid, 29.1% protein, 6.3% deoxyribonucleic acid, and 4.0% hexose. Ultracentrifugation studies indicated that this extract had five constituents which are compatible with ribosomal material.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16557934-13192056, http://linkedlifedata.com/resource/pubmed/commentcorrection/16557934-13293190, http://linkedlifedata.com/resource/pubmed/commentcorrection/16557934-13301496, http://linkedlifedata.com/resource/pubmed/commentcorrection/16557934-13908572, http://linkedlifedata.com/resource/pubmed/commentcorrection/16557934-14293000, http://linkedlifedata.com/resource/pubmed/commentcorrection/16557934-16557778, http://linkedlifedata.com/resource/pubmed/commentcorrection/16557934-16557782, http://linkedlifedata.com/resource/pubmed/commentcorrection/16557934-4190969, http://linkedlifedata.com/resource/pubmed/commentcorrection/16557934-4383135, http://linkedlifedata.com/resource/pubmed/commentcorrection/16557934-4898982, http://linkedlifedata.com/resource/pubmed/commentcorrection/16557934-4957609, http://linkedlifedata.com/resource/pubmed/commentcorrection/16557934-4957610, http://linkedlifedata.com/resource/pubmed/commentcorrection/16557934-5231416, http://linkedlifedata.com/resource/pubmed/commentcorrection/16557934-5853159
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:month
Jan
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
16-23
pubmed:dateRevised
2010-9-14
pubmed:year
1971
pubmed:articleTitle
Protection against pneumococcal infection by a ribosomal preparation.
pubmed:affiliation
Department of Microbiology, College of Medicine, University of Iowa, Iowa City, Iowa 52240.
pubmed:publicationType
Journal Article