Linked Life Data

16546687

Source:http://linkedlifedata.com/resource/pubmed/id/16546687

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2006-3-20
pubmed:abstractText
Interactions between platelets and leukocytes link critical thrombotic and inflammatory events that control an array of cardiovascular syndromes. In atherosclerosis alone, inducible gene expression in platelets and leukocytes modulates the initiation and development of vulnerable plaques that increase a patient's risk for acute coronary events. Interruption of gene expression pathways that are triggered when platelets adhere to leukocytes may be a new target for therapeutic intervention. Recent evidence indicates that dipyridamole, an old drug with a diverse history, differentially inhibits gene expression in platelet-leukocyte aggregates by exerting its effect at distinct molecular checkpoints.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1050-1738
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
75-80
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
New roles for an old drug: inhibition of gene expression by dipyridamole in platelet-leukocyte aggregates.
pubmed:affiliation
Department of Internal Medicine, University of Utah, Salt Lake City, UT 84112, USA. andy.weyrich@hmbg.utah.edu
pubmed:publicationType
Journal Article, Review