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rdf:type |
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lifeskim:mentions |
umls-concept:C0006142,
umls-concept:C0021102,
umls-concept:C0086418,
umls-concept:C0439851,
umls-concept:C0851285,
umls-concept:C0879457,
umls-concept:C1517499,
umls-concept:C1517564,
umls-concept:C1533685,
umls-concept:C1552596,
umls-concept:C1947931
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pubmed:dateCreated |
2006-5-18
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pubmed:abstractText |
HSVtk/ganciclovir (GCV) gene therapy has been extensively studied in tumors and relies largely on the gene expression of HSVtk. Most studies, however, have failed to demonstrate any significant benefit of a controlled gene expression strategy in cancer treatment. The Tet-On system is commonly used to regulate gene expression following Dox induction. We have evaluated the antitumor effect of HSVtk/ganciclovir gene therapy under Tet-On regulation by means of adeno-associated virus-2 (AAV-2)-mediated HSVtk gene transfer with direct intratumoral injections in mice bearing breast cancer tumors.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-10430060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-10543610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-10680842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-10738580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-10811478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-10859354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-10866313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-11268284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-11773979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-11821934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-11859419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-11892834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-12080384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-12525840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-12649173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-12651152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-12758130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-12946317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-14538060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-14681727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-14687938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-14960361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-15043787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-15072465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-15087396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-15093189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-15120326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-15138367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-15194049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-15232602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-15375516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-15474666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-15509510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-16110312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-7792603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16539746-9536267
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2407
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
66
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16539746-Adenocarcinoma,
pubmed-meshheading:16539746-Animals,
pubmed-meshheading:16539746-Antiviral Agents,
pubmed-meshheading:16539746-Breast Neoplasms,
pubmed-meshheading:16539746-Cell Line, Tumor,
pubmed-meshheading:16539746-Dependovirus,
pubmed-meshheading:16539746-Doxycycline,
pubmed-meshheading:16539746-Enzyme Induction,
pubmed-meshheading:16539746-Female,
pubmed-meshheading:16539746-Ganciclovir,
pubmed-meshheading:16539746-Gene Expression Regulation, Viral,
pubmed-meshheading:16539746-Gene Therapy,
pubmed-meshheading:16539746-Genes, Synthetic,
pubmed-meshheading:16539746-Genes, Transgenic, Suicide,
pubmed-meshheading:16539746-Genetic Vectors,
pubmed-meshheading:16539746-Humans,
pubmed-meshheading:16539746-Injections, Intralesional,
pubmed-meshheading:16539746-Mice,
pubmed-meshheading:16539746-Mice, Inbred BALB C,
pubmed-meshheading:16539746-Mice, Nude,
pubmed-meshheading:16539746-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:16539746-Simplexvirus,
pubmed-meshheading:16539746-Thymidine Kinase,
pubmed-meshheading:16539746-Xenograft Model Antitumor Assays
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pubmed:year |
2006
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pubmed:articleTitle |
Recombinant AAV-mediated HSVtk gene transfer with direct intratumoral injections and Tet-On regulation for implanted human breast cancer.
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pubmed:affiliation |
Molecular Biology Research Center, Xiangya Medical College, Central South University, Changsha, Hunan 410078, PR China. Lzb1022@hotmail.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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