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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2006-5-16
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pubmed:abstractText |
As inactivation of p53 may be correlated with poor response of tumors to chemo- and/or radiotherapy the presence of p53 mutations in exons 5-8 was determined in adenocarcinomas of the gastroesophageal junction (GEJ). As p53 protein phosphorylation at serine 15 indicates stabilization and protection against mdm-2 the presence of this phosphorylation state was subsequently evaluated.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0171-5216
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
132
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
433-8
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16538517-Adenocarcinoma,
pubmed-meshheading:16538517-Base Sequence,
pubmed-meshheading:16538517-Chromatography, High Pressure Liquid,
pubmed-meshheading:16538517-Clinical Trials, Phase III as Topic,
pubmed-meshheading:16538517-Combined Modality Therapy,
pubmed-meshheading:16538517-Esophageal Neoplasms,
pubmed-meshheading:16538517-Esophagogastric Junction,
pubmed-meshheading:16538517-Genes, p53,
pubmed-meshheading:16538517-Humans,
pubmed-meshheading:16538517-Multicenter Studies as Topic,
pubmed-meshheading:16538517-Mutation,
pubmed-meshheading:16538517-Phosphorylation,
pubmed-meshheading:16538517-Predictive Value of Tests,
pubmed-meshheading:16538517-Prognosis,
pubmed-meshheading:16538517-Prospective Studies,
pubmed-meshheading:16538517-Sequence Analysis, DNA,
pubmed-meshheading:16538517-Serine,
pubmed-meshheading:16538517-Stomach Neoplasms,
pubmed-meshheading:16538517-Survival Analysis,
pubmed-meshheading:16538517-Tumor Suppressor Protein p53
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pubmed:year |
2006
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pubmed:articleTitle |
Lack of prognostic impact of p53 gene mutation and p53 phosphorylation at serine 15 in multimodally treated adenocarcinomas of the gastroesophageal junction.
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pubmed:affiliation |
Institute of Pathology, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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