| pubmed-article:16534739 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16534739 | lifeskim:mentions | umls-concept:C1465029 | lld:lifeskim |
| pubmed-article:16534739 | lifeskim:mentions | umls-concept:C0001128 | lld:lifeskim |
| pubmed-article:16534739 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:16534739 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:16534739 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:16534739 | lifeskim:mentions | umls-concept:C0630889 | lld:lifeskim |
| pubmed-article:16534739 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16534739 | pubmed:dateCreated | 2006-3-14 | lld:pubmed |
| pubmed-article:16534739 | pubmed:abstractText | Gambogic acid, usually isolated as an inseparable stereomeric mixture of C-2 epimers, was newly separated into two epimers (1 and 2) from the gamboges of Garcinia hanburyi. The stereochemistry at C-2 was clearly defined by extensive spectroscopic analysis and direct comparison of NMR and HPLC data with those of the known R-epimer. Both epimers were examined for their cytotoxicities against human leukemia K562 (K562/S) and doxorubicin-resistant K562 (K562/R) cell lines. Different from doxorubicin (IC (50) = 10.78 microM for K562/R and 0.66 microM for K562/S), epimers 1 and 2 exhibited similar activities against both cell lines (IC(50) = 1.32 and 0.89 microM for 1, IC(50) = 1.11 and 0.86 microM for 2). These results suggested that both epimers were not multidrug resistance (MDR) substrates. Furthermore, epimers 1 and 2 were tested for their inhibitory effects against six human cytochrome P-450 enzymes. Epimers 1 and 2 showed little inhibitory effects toward five of the enzymes except CYP2C9. Interestingly, when tested against CYP2C9, S-epimer 2 had an inhibitory effect 20-fold stronger than that of R-epimer 1. | lld:pubmed |
| pubmed-article:16534739 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16534739 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16534739 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16534739 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16534739 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16534739 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16534739 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16534739 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16534739 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16534739 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:16534739 | pubmed:issn | 0032-0943 | lld:pubmed |
| pubmed-article:16534739 | pubmed:author | pubmed-author:LiuYongY | lld:pubmed |
| pubmed-article:16534739 | pubmed:author | pubmed-author:YangLingL | lld:pubmed |
| pubmed-article:16534739 | pubmed:author | pubmed-author:WangYulinY | lld:pubmed |
| pubmed-article:16534739 | pubmed:author | pubmed-author:XuHongxiH | lld:pubmed |
| pubmed-article:16534739 | pubmed:author | pubmed-author:HanQuanbinQ | lld:pubmed |
| pubmed-article:16534739 | pubmed:author | pubmed-author:YangDajianD | lld:pubmed |
| pubmed-article:16534739 | pubmed:author | pubmed-author:QiaoChunfengC | lld:pubmed |
| pubmed-article:16534739 | pubmed:author | pubmed-author:SongJingzheng... | lld:pubmed |
| pubmed-article:16534739 | pubmed:author | pubmed-author:XuLijiaL | lld:pubmed |
| pubmed-article:16534739 | pubmed:author | pubmed-author:ChenShilinS | lld:pubmed |
| pubmed-article:16534739 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16534739 | pubmed:volume | 72 | lld:pubmed |
| pubmed-article:16534739 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16534739 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16534739 | pubmed:pagination | 281-4 | lld:pubmed |
| pubmed-article:16534739 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:16534739 | pubmed:meshHeading | pubmed-meshheading:16534739... | lld:pubmed |
| pubmed-article:16534739 | pubmed:meshHeading | pubmed-meshheading:16534739... | lld:pubmed |
| pubmed-article:16534739 | pubmed:meshHeading | pubmed-meshheading:16534739... | lld:pubmed |
| pubmed-article:16534739 | pubmed:meshHeading | pubmed-meshheading:16534739... | lld:pubmed |
| pubmed-article:16534739 | pubmed:meshHeading | pubmed-meshheading:16534739... | lld:pubmed |
| pubmed-article:16534739 | pubmed:meshHeading | pubmed-meshheading:16534739... | lld:pubmed |
| pubmed-article:16534739 | pubmed:meshHeading | pubmed-meshheading:16534739... | lld:pubmed |
| pubmed-article:16534739 | pubmed:meshHeading | pubmed-meshheading:16534739... | lld:pubmed |
| pubmed-article:16534739 | pubmed:meshHeading | pubmed-meshheading:16534739... | lld:pubmed |
| pubmed-article:16534739 | pubmed:meshHeading | pubmed-meshheading:16534739... | lld:pubmed |
| pubmed-article:16534739 | pubmed:meshHeading | pubmed-meshheading:16534739... | lld:pubmed |
| pubmed-article:16534739 | pubmed:meshHeading | pubmed-meshheading:16534739... | lld:pubmed |
| pubmed-article:16534739 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16534739 | pubmed:articleTitle | Gambogic acid and epigambogic acid, C-2 epimers with novel anticancer effects from Garcinia hanburyi. | lld:pubmed |
| pubmed-article:16534739 | pubmed:affiliation | Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Shatin, NT, PR China. | lld:pubmed |
| pubmed-article:16534739 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16534739 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16534739 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16534739 | lld:pubmed |
