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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2006-6-5
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pubmed:abstractText |
The protopine isolated from a Chinese herb Dactylicapnos scandens Hutch was identified as an inhibitor of both serotonin transporter and noradrenaline transporter in vitro assays. 5-hydroxy-DL-tryptophan(5-HTP)-induced head twitch response (HTR) and tail suspension test were adopted to study whether protopine has anti-depression effect in mice using reference antidepressant fluoxetine and desipramine as positive controls. In HTR test, protopine at doses of 5, 10, 20 mg/kg dose dependently increase the number of 5-HTP-induced HTR. Protopine at doses of 3.75 mg/kg, 7.5 mg/kg and 30 mg/kg also produces a dose-dependent reduction in immobility in the tail suspension test. The present results open up new possibilities for the use of protopine in the treatment of mood disorders, such as mild and moderate states of depression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0028-3908
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
934-40
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16530230-Analysis of Variance,
pubmed-meshheading:16530230-Animals,
pubmed-meshheading:16530230-Antidepressive Agents,
pubmed-meshheading:16530230-Behavior, Animal,
pubmed-meshheading:16530230-Benzophenanthridines,
pubmed-meshheading:16530230-Berberine Alkaloids,
pubmed-meshheading:16530230-CHO Cells,
pubmed-meshheading:16530230-Cricetinae,
pubmed-meshheading:16530230-Cricetulus,
pubmed-meshheading:16530230-Depression,
pubmed-meshheading:16530230-Disease Models, Animal,
pubmed-meshheading:16530230-Dose-Response Relationship, Drug,
pubmed-meshheading:16530230-Head Movements,
pubmed-meshheading:16530230-Hindlimb Suspension,
pubmed-meshheading:16530230-Inhibitory Concentration 50,
pubmed-meshheading:16530230-Male,
pubmed-meshheading:16530230-Mice,
pubmed-meshheading:16530230-Mice, Inbred BALB C,
pubmed-meshheading:16530230-Motor Activity,
pubmed-meshheading:16530230-Norepinephrine Plasma Membrane Transport Proteins,
pubmed-meshheading:16530230-Protein Binding,
pubmed-meshheading:16530230-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:16530230-Tetrazolium Salts,
pubmed-meshheading:16530230-Thiazoles,
pubmed-meshheading:16530230-Transfection
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pubmed:year |
2006
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pubmed:articleTitle |
Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models.
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pubmed:affiliation |
Shanghai Celstar Institute of Biotechnology, 1 Ju Li Road, Shanghai 201203, People's Republic of China.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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