Linked Life Data

16528543

Source:http://linkedlifedata.com/resource/pubmed/id/16528543

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2006-5-16
pubmed:abstractText
Acute kidney injury secondary to ischemia-reperfusion in renal allografts often results in delayed graft function. We tested the hypothesis that expression of neutrophil gelatinase-associated lipocalin (NGAL) is an early marker of acute kidney injury following transplantation. Sections from paraffin-embedded protocol biopsy specimens obtained at approximately one hour of reperfusion after transplantation of 13 cadaveric (CAD) and 12 living-related (LRD) renal allografts were examined by immunohistochemistry for expression of NGAL. The staining intensity was correlated with cold ischemia time, peak post-operative serum creatinine, and dialysis requirement. There were no differences between the LRD and CAD groups in age, gender or preoperative serum creatinine. Using a scoring system of 0 (no staining) to 3 (most intense staining), NGAL expression was significantly increased in CAD specimens (2.3+/-0.8 versus 0.8+/-0.7 in LRD, p<0.001). There was a strong correlation between NGAL staining intensity and cold ischemia time (R=0.87, p<0.001). Importantly, NGAL staining in these early CAD biopsies was strongly correlated with peak postoperative serum creatinine, which occurred days later (R=0.86, p<0.001). Four patients developed delayed graft function requiring dialysis during the first week posttransplantation; all of these patients displayed the most intense NGAL staining in their first protocol biopsies. We conclude that NGAL staining intensity in early protocol biopsies represents a novel predictive biomarker of acute kidney injury following transplantation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0931-041X
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
856-63
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:16528543-Acute Kidney Injury, pubmed-meshheading:16528543-Acute-Phase Proteins, pubmed-meshheading:16528543-Adolescent, pubmed-meshheading:16528543-Adult, pubmed-meshheading:16528543-Biological Markers, pubmed-meshheading:16528543-Cadaver, pubmed-meshheading:16528543-Child, pubmed-meshheading:16528543-Delayed Graft Function, pubmed-meshheading:16528543-Female, pubmed-meshheading:16528543-Humans, pubmed-meshheading:16528543-Kidney, pubmed-meshheading:16528543-Kidney Transplantation, pubmed-meshheading:16528543-Lipocalins, pubmed-meshheading:16528543-Living Donors, pubmed-meshheading:16528543-Male, pubmed-meshheading:16528543-Prognosis, pubmed-meshheading:16528543-Proto-Oncogene Proteins, pubmed-meshheading:16528543-Reperfusion Injury, pubmed-meshheading:16528543-Tissue Donors
pubmed:year
2006
pubmed:articleTitle
Kidney NGAL is a novel early marker of acute injury following transplantation.
pubmed:affiliation
Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural