Linked Life Data

16518644

Source:http://linkedlifedata.com/resource/pubmed/id/16518644

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2006-8-9
pubmed:abstractText
Many cases of hepatopathy including deaths have frequently occurred after ingestion of Chinese dietary supplements for weight loss containing N-nitrosofenfluramine (N-fen), a nitroso derivative of fenfluramine (Fen), which was used for the treatment of obesity in the United States. Since Fen decreases appetite by decreasing the serotonin level and exhibits an antibiotic effect, N-fen may have been added, expecting a similar effect. Thus, we synthesized N-fen and orally administered it to mice, and investigated its effect on the liver as well as on the cerebral serotonin nervous system to investigate whether N-fen exhibits an anorectic effect. Three doses of N-fen were orally administered once daily to mice for 1 week. No significant changes in body weight, food intake, and general condition were noted. The liver and kidney weights were significantly increased. On blood chemistry, alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase activities were increased, and total bilirubin and albumin were slightly decreased. On histopathological examination, acidophilic changes and mild cellular swelling were noted in the liver. The liver drug-metabolizing enzyme (P-450) level was significantly higher. The effect of N-fen on the serotonin (5HT) nervous system was examined by quantitative autoradiography of the mouse brain, and it was found that N-fen did not decrease the 5HT nerve activity. Effects of reuptake and release of monoamine neurotransmitters [dopamine (DA), 5HT, and norepinephrine (NE)] were investigated. N-fen inhibited a little 5HT reuptake, and did not inhibit reuptakes of DA and NE. Moreover, N-fen did not affect release of the three monoamines. The above findings suggested that N-fen did not exhibit a serotonin nerve fiber-mediated anorectic effect in mice, but induced hepatopathy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0340-5761
pubmed:author
pubmed:issnType
Print
pubmed:volume
80
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
605-13
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:16518644-Administration, Oral, pubmed-meshheading:16518644-Animals, pubmed-meshheading:16518644-Anti-Obesity Agents, pubmed-meshheading:16518644-Brain, pubmed-meshheading:16518644-Cytochrome P-450 Enzyme System, pubmed-meshheading:16518644-Dietary Supplements, pubmed-meshheading:16518644-Dose-Response Relationship, Drug, pubmed-meshheading:16518644-Drug-Induced Liver Injury, pubmed-meshheading:16518644-Drugs, Chinese Herbal, pubmed-meshheading:16518644-Fenfluramine, pubmed-meshheading:16518644-Kidney, pubmed-meshheading:16518644-Liver, pubmed-meshheading:16518644-Male, pubmed-meshheading:16518644-Mice, pubmed-meshheading:16518644-Mice, Inbred ICR, pubmed-meshheading:16518644-Neurotransmitter Uptake Inhibitors, pubmed-meshheading:16518644-Organ Size, pubmed-meshheading:16518644-Serotonin, pubmed-meshheading:16518644-Toxicity Tests
pubmed:year
2006
pubmed:articleTitle
Effects of N-nitrosofenfluramine, a component of Chinese dietary supplement for weight loss, on CD-1 mice.
pubmed:affiliation
Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health, 24-1 Hyakunincho 3-chome, 169-0073 Shinjuku-ku, Tokyo, Japan. Kanako_Satou@member.metro.tokyo.jp
pubmed:publicationType
Journal Article