rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
3
|
pubmed:dateCreated |
2006-3-3
|
pubmed:abstractText |
18F-2beta-Carbomethoxy-3beta-(4-chlorophenyl)-8-(2-fluoroethyl)nortropane (18F-FECNT), a PET radioligand for the dopamine transporter (DAT), generates a radiometabolite that enters the rat brain. The aims of this study were to characterize this radiometabolite and to determine whether a similar phenomenon occurs in human and nonhuman primate brains by examining the stability of the apparent distribution volume in DAT-rich (striatum) and DAT-poor (cerebellum) regions of the brain.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
0161-5505
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
47
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
520-7
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:16513622-Animals,
pubmed-meshheading:16513622-Cerebellum,
pubmed-meshheading:16513622-Corpus Striatum,
pubmed-meshheading:16513622-Dopamine Plasma Membrane Transport Proteins,
pubmed-meshheading:16513622-Female,
pubmed-meshheading:16513622-Humans,
pubmed-meshheading:16513622-Macaca mulatta,
pubmed-meshheading:16513622-Male,
pubmed-meshheading:16513622-Metabolic Clearance Rate,
pubmed-meshheading:16513622-Nortropanes,
pubmed-meshheading:16513622-Radiopharmaceuticals,
pubmed-meshheading:16513622-Rats,
pubmed-meshheading:16513622-Rats, Sprague-Dawley,
pubmed-meshheading:16513622-Tissue Distribution
|
pubmed:year |
2006
|
pubmed:articleTitle |
PET imaging of the dopamine transporter with 18F-FECNT: a polar radiometabolite confounds brain radioligand measurements.
|
pubmed:affiliation |
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-0135, USA. zoghbis@mail.nih.gov
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Intramural
|