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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
Pt 1
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pubmed:dateCreated |
2006-3-1
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pubmed:abstractText |
Group I introns are catalytic RNAs that are capable of performing a variety of phosphotransesterification reactions including self-splicing and RNA cleavage. The reactions are efficient, accurate and dependent only on the presence of guanosine-nucleotide substrate and sufficient magnesium ion to stabilize the structure of the RNA. To understand how the group I intron active-site facilitates catalysis, crystals of a 242-nucleotide ribozyme bound to a four-nucleotide product RNA have been produced that diffract to 3.6 A resolution. The space group of these crystals is I2(1)2(1)2(1) and the unit-cell parameters are a = 94.6, b = 141.0, c = 210.9 A. A single heavy-atom derivative has been synthesized by covalent modification of the product RNA with iodine.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16508095-10359829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16508095-11286889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16508095-11318638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16508095-12718923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16508095-15175762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16508095-2017681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16508095-2271645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16508095-2685606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16508095-3069131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16508095-6297745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16508095-7545072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16508095-8359471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16508095-8422962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16508095-8781224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16508095-9245599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16508095-9757107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16508095-9841391
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1744-3091
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
71-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16508095-Base Sequence,
pubmed-meshheading:16508095-Cloning, Molecular,
pubmed-meshheading:16508095-DNA Primers,
pubmed-meshheading:16508095-Introns,
pubmed-meshheading:16508095-Models, Molecular,
pubmed-meshheading:16508095-Molecular Sequence Data,
pubmed-meshheading:16508095-Nucleic Acid Conformation,
pubmed-meshheading:16508095-RNA, Catalytic,
pubmed-meshheading:16508095-RNA, Viral,
pubmed-meshheading:16508095-RNA Splicing,
pubmed-meshheading:16508095-Staphylococcus Phages
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pubmed:year |
2005
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pubmed:articleTitle |
Crystallization and preliminary diffraction analysis of a group I ribozyme from bacteriophage Twort.
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pubmed:affiliation |
Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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