Linked Life Data

16497794

Source:http://linkedlifedata.com/resource/pubmed/id/16497794

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2006-5-18
pubmed:abstractText
Although the blood-brain barrier limits free passage of peptides and proteins from the peripheral circulation to the central nervous system, specific transport systems for insulin and IGF-I have been identified. To further determine whether insulin and IGF-I share the same transport system, and if not, whether the two transport systems interact with each other, we performed multiple-time regression analysis in mice after iv injection and in situ brain perfusion of these peptides. Insulin and IGF-I caused reciprocal inhibition of each other's transport, although the effect of insulin was detected only by the in situ brain perfusion system. The interaction took place mainly at the step of cell surface binding as seen in cultured rat brain endothelium 4 brain microvessel endothelial cells. Further studies in 3T3 cells stably overexpressing the insulin receptor showed that the sharing of the transport systems was only partial. We conclude that insulin and IGF-I are mainly transported by their own transport systems, but a small amount can enter the brain by their "noncognate" transporters. The redundancy of their transport systems illustrates the regulatory function of the blood-brain barrier and reflects the importance of blood-borne insulin and IGF-I in the central nervous system.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0013-7227
pubmed:author
pubmed:issnType
Print
pubmed:volume
147
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2611-5
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Reciprocal interactions of insulin and insulin-like growth factor I in receptor-mediated transport across the blood-brain barrier.
pubmed:affiliation
Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA. weihong.pan@pbrc.edu
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural