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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2006-2-22
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pubmed:abstractText |
The oral hypoglycaemic sulphonylurea glibenclamide stimulates endogenous insulin secretion through blockade of ATP-sensitive potassium (KATP) channels on pancreatic beta cells, but also blocks cardiovascular KATP channels, leading to increased peripheral vascular resistance and reduced peripheral blood flow in non-diabetic subjects. Therefore, this study examined whether a single oral dose of glibenclamide adversely affected the pain-free or maximal walking distance in patients with intermittent claudication.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0742-3071
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
327-30
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16492219-Adenosine Triphosphate,
pubmed-meshheading:16492219-Administration, Oral,
pubmed-meshheading:16492219-Aged,
pubmed-meshheading:16492219-Blood Glucose,
pubmed-meshheading:16492219-Blood Pressure,
pubmed-meshheading:16492219-Cross-Over Studies,
pubmed-meshheading:16492219-Double-Blind Method,
pubmed-meshheading:16492219-Exercise Test,
pubmed-meshheading:16492219-Female,
pubmed-meshheading:16492219-Glyburide,
pubmed-meshheading:16492219-Humans,
pubmed-meshheading:16492219-Hypoglycemic Agents,
pubmed-meshheading:16492219-Insulin,
pubmed-meshheading:16492219-Intermittent Claudication,
pubmed-meshheading:16492219-Male,
pubmed-meshheading:16492219-Middle Aged,
pubmed-meshheading:16492219-Pain,
pubmed-meshheading:16492219-Potassium,
pubmed-meshheading:16492219-Potassium Channel Blockers,
pubmed-meshheading:16492219-Serum Albumin,
pubmed-meshheading:16492219-Walking
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pubmed:year |
2006
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pubmed:articleTitle |
Effect of the oral hypoglycaemic sulphonylurea glibenclamide, a blocker of ATP-sensitive potassium channels, on walking distance in patients with intermittent claudication.
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pubmed:affiliation |
Department of Cardiology B, Aarhus University Hospital, Aarhus, Denmark.
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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