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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2006-3-28
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pubmed:abstractText |
Thymidylate synthase (TS) catalyzes the methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP) and is a key enzyme for DNA synthesis. High expression of TS is thought to be associated with poor prognosis in some kinds of cancers. However, this association has not been clarified for nonsmall cell lung carcinoma. In the current study, the authors investigated the clinicopathologic significance of TS mRNA levels and the correlation with cellular proliferation in patients with lung adenocarcinoma.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0008-543X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2006 American Cancer Society.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1595-601
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pubmed:meshHeading |
pubmed-meshheading:16489621-Adenocarcinoma,
pubmed-meshheading:16489621-Aged,
pubmed-meshheading:16489621-Aged, 80 and over,
pubmed-meshheading:16489621-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:16489621-Cell Proliferation,
pubmed-meshheading:16489621-Female,
pubmed-meshheading:16489621-Gene Expression Profiling,
pubmed-meshheading:16489621-Humans,
pubmed-meshheading:16489621-Immunohistochemistry,
pubmed-meshheading:16489621-Lung Neoplasms,
pubmed-meshheading:16489621-Lymphatic Metastasis,
pubmed-meshheading:16489621-Male,
pubmed-meshheading:16489621-Middle Aged,
pubmed-meshheading:16489621-Neoplasm Staging,
pubmed-meshheading:16489621-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16489621-Thymidylate Synthase
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pubmed:year |
2006
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pubmed:articleTitle |
Significance of thymidylate synthase gene expression level in patients with adenocarcinoma of the lung.
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pubmed:affiliation |
Department of Surgery II, National Defense Medical College, Saitama, Japan.
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pubmed:publicationType |
Journal Article
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