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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1991-8-21
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pubmed:abstractText |
The invasiveness of MCF-7 human mammary carcinoma cells was tested in vitro via confronting cultures with embryonic chick heart fragments. Invasive (e.g. MCF-7/6) and non-invasive (e.g. MCF-7/AZ) variants were detected. Automated image analysis of time-lapse video-microscopy recordings showed that the plasma membrane ruffling activity of the invasive MCF-7/6 variant was higher than the ruffling activity of the non-invasive MCF-7/AZ variant. Addition of all-trans-retinoic acid to the culture medium (10(-6) M) inhibited both invasion and ruffling of MCF-7/6 cells, while MCF-7/AZ cells became invasive and acquired an increased ruffling by the same type of treatment. A similar opposite effect on MCF-7 cells was not found after treatment with other ligands of the nuclear steroid/thyroid receptor superfamily. Triiodo-l-thyronine (up to 10(-5) M) and beta-oestradiol (up to 10(-6) M) did not alter the invasiveness of the cells, while dexamethasone (10(-6) M) and the pure anti-oestrogen ICI 164,384 inhibited both invasion and ruffling. Our data show that retinoic acid can modulate invasiveness in opposite directions.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-2153689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-2162253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-2170280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-2203690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-2299598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-2465358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-2466710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-2470609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-2504935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-2538232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-2582435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-2613755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-2752606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-2823256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-2825024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-2825025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-2825036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-2848197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-2905883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-2921279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-2946041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-2998604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-3061678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-3145193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-3163940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-3332658,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-3417370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-3691670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-3731075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-37648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-4030624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-4288553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-4357757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-481604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-6498837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-6543696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-6567481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-6831445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-7055809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1648947-7188386
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0007-0920
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
63
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
867-72
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1648947-Animals,
pubmed-meshheading:1648947-Breast Neoplasms,
pubmed-meshheading:1648947-Cell Aggregation,
pubmed-meshheading:1648947-Cell Division,
pubmed-meshheading:1648947-Cell Line,
pubmed-meshheading:1648947-Cell Membrane,
pubmed-meshheading:1648947-Chick Embryo,
pubmed-meshheading:1648947-Dexamethasone,
pubmed-meshheading:1648947-Estradiol,
pubmed-meshheading:1648947-Estrogen Antagonists,
pubmed-meshheading:1648947-Female,
pubmed-meshheading:1648947-Humans,
pubmed-meshheading:1648947-Myocardium,
pubmed-meshheading:1648947-Neoplasm Invasiveness,
pubmed-meshheading:1648947-Polyunsaturated Alkamides,
pubmed-meshheading:1648947-Receptors, Cell Surface,
pubmed-meshheading:1648947-Tretinoin,
pubmed-meshheading:1648947-Triiodothyronine
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pubmed:year |
1991
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pubmed:articleTitle |
Retinoic acid modulates both invasion and plasma membrane ruffling of MCF-7 human mammary carcinoma cells in vitro.
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pubmed:affiliation |
Department of Radiotherapy and Nuclear Medicine, University Hospital, Gent, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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