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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2006-2-17
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pubmed:abstractText |
The aim of this study was to describe the clinical experience in 184 consecutive stroke patients first-ever treated with recombinant tissue plasminogen activator (rt-PA) at a single Dutch centre, with special emphasis on results among the very old. Outcome parameters were the modified Rankin scale (mRs) at 3 months and symptomatic intracranial haemorrhage (SICH). Outcome was related to age. A total of 184 patients were treated of whom 45 were 80 years of age or older (24%). Sixty two (45%) of 139 patients < 80 years of age and 12 (27%) of 45 patients > or = 80 years of age had a favourable outcome defined as an mRs score of 0 or 1 (OR 2.21; 95% CI: 1.06 to 4.46). There was a good outcome (mRs score < or = 2) in 88 (63%) and 16 (36%) patients, respectively (OR 3.13; 95% CI: 1.55 to 6.30). SICH was observed in four of 139 (2.9%) patients < 80 years of age and in five of 45 (11.1%) patients > or = 80 years of age (OR 4.22; 95% CI: 1.08 to 16.46). The results of this study underline the uncertainty regarding the risk/benefit ratio of rt-PA treatment in acute stroke in patients over 80 years of age.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16484647-10657408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16484647-10703776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16484647-10703782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16484647-11108749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16484647-11340212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16484647-12560250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16484647-14960429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16484647-14960430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16484647-15778105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16484647-16484633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16484647-7477192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16484647-7563451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16484647-7974549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16484647-9445322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16484647-9707190
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-3050
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
375-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16484647-Activities of Daily Living,
pubmed-meshheading:16484647-Age Factors,
pubmed-meshheading:16484647-Aged, 80 and over,
pubmed-meshheading:16484647-Brain Damage, Chronic,
pubmed-meshheading:16484647-Female,
pubmed-meshheading:16484647-Humans,
pubmed-meshheading:16484647-Infarction, Middle Cerebral Artery,
pubmed-meshheading:16484647-Intracranial Hemorrhages,
pubmed-meshheading:16484647-Male,
pubmed-meshheading:16484647-Risk Assessment,
pubmed-meshheading:16484647-Thrombolytic Therapy,
pubmed-meshheading:16484647-Tissue Plasminogen Activator,
pubmed-meshheading:16484647-Treatment Outcome
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pubmed:year |
2006
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pubmed:articleTitle |
Thrombolysis for acute stroke with special emphasis on the very old: experience from a single Dutch centre.
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pubmed:affiliation |
Department of Neurology, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands. rvoo@sneu.azm.nl
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pubmed:publicationType |
Journal Article
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