Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1991-8-1
|
| pubmed:abstractText |
Pretest exposure to novelty or injections of beta-endorphin can enhance passive avoidance (PA) retention (e.g., Izquierdo & McGaugh, 1985). Enhanced retention may result from a "state-dependent" match between the CNS state during test and the novelty-induced beta-endorphin state that is obtained during training in a novel apparatus. Our Experiment 1 suggests that, unlike PA, Pavlovian fear conditioning in a conditioned lick suppression (CLS) paradigm may be beta-endorphin "state-independent." Rats were given one tone-shock pairing in a novel environment. Baseline lick rates and CLS tested 48 h later in a familiar environment were not affected by pretest exposure to novelty and/or injections of 3.33 mg/kg naloxone HCl. In Experiment 2, the same rats were PA trained/tested in a new apparatus. Saline or naloxone injections and various exposure (novel, familiar, none) conditions preceded (1h) the 24-h retention test. Pretest exposure to novelty reduced retention and naloxone eliminated that deficit. In Experiment 3, naive rats given pretest exposure to novelty also showed a PA retention deficit. The results of Experiments 2 and 3 may complement rather than contradict previous findings. Pretest induction of a beta-endorphin state by novelty may either enhance state-dependent retrieval of a "weak" memory trace or make a "strong/well consolidated" training memory more vulnerable to retroactive interference from "new learning" during the pretest exposure period.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0163-1047
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
55
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
270-88
|
| pubmed:dateRevised |
2006-5-16
|
| pubmed:meshHeading |
pubmed-meshheading:1647763-Animals,
pubmed-meshheading:1647763-Appetitive Behavior,
pubmed-meshheading:1647763-Arousal,
pubmed-meshheading:1647763-Association Learning,
pubmed-meshheading:1647763-Attention,
pubmed-meshheading:1647763-Avoidance Learning,
pubmed-meshheading:1647763-Brain,
pubmed-meshheading:1647763-Conditioning, Classical,
pubmed-meshheading:1647763-Drinking,
pubmed-meshheading:1647763-Male,
pubmed-meshheading:1647763-Naloxone,
pubmed-meshheading:1647763-Rats,
pubmed-meshheading:1647763-Rats, Inbred Strains,
pubmed-meshheading:1647763-Receptors, Opioid,
pubmed-meshheading:1647763-Retention (Psychology),
pubmed-meshheading:1647763-Social Environment,
pubmed-meshheading:1647763-beta-Endorphin
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Naloxone eliminates passive avoidance retention deficits produced by pretest exposure to novelty in rats.
|
| pubmed:affiliation |
Department of Psychology, University of Missouri, Columbia 65211.
|
| pubmed:publicationType |
Journal Article
|