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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1A
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pubmed:dateCreated |
2006-2-14
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pubmed:abstractText |
Adhesion to extracellular matrix (ECM) proteins and degradation of basement membranes by matrix metalloproteinase (MMP) play important roles in cancer metastasis. In this study, the effects of gefitinib on the enzymatic activity of MMP and adhesion to ECM proteins in the HT29 colon cancer cell line were investigated.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0250-7005
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
129-34
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16475688-Antineoplastic Agents,
pubmed-meshheading:16475688-Apoptosis,
pubmed-meshheading:16475688-Blotting, Western,
pubmed-meshheading:16475688-Cell Adhesion,
pubmed-meshheading:16475688-Cell Growth Processes,
pubmed-meshheading:16475688-Colonic Neoplasms,
pubmed-meshheading:16475688-Extracellular Matrix Proteins,
pubmed-meshheading:16475688-HT29 Cells,
pubmed-meshheading:16475688-Humans,
pubmed-meshheading:16475688-Matrix Metalloproteinase 2,
pubmed-meshheading:16475688-Matrix Metalloproteinase 9,
pubmed-meshheading:16475688-Quinazolines
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pubmed:articleTitle |
Gefitinib decreases the synthesis of matrix metalloproteinase and the adhesion to extracellular matrix proteins of colon cancer cells.
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pubmed:affiliation |
Department of Cancer and Thoracic Surgery, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan. todadkoc@umin.ac.jp
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pubmed:publicationType |
Journal Article
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