Linked Life Data

1647323

Source:http://linkedlifedata.com/resource/pubmed/id/1647323

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1991-7-31
pubmed:abstractText
A transient outward current (Ito) was elicited by depolarization in single smooth muscle cells isolated from guinea-pig vas deferens under whole-cell voltage-clamp conditions. The peak amplitude of Ito was markedly decreased by over 80% within 10 s after application of 10 microM noradrenaline. When the pipette solution contained low molecular weight heparin (0.3-5 mg/ml), the inhibitory effect of 10 microM noradrenaline on Ito was apparently reduced. Our results strongly suggest that the noradrenaline-induced suppression of Ito is an event subsequent to Ca2+ release and depletion of available Ca2+ stored in the sarcoplasmic reticulum (SR) by myo-inositol 1,4,5-trisphosphate (InsP3), an event which is blocked by low molecular weight heparin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
14
pubmed:volume
193
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
375-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Effects of noradrenaline and heparin on outward current in single smooth muscle cells of the guinea-pig vas deferens.
pubmed:affiliation
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't