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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-3-31
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pubmed:abstractText |
Cardiomyocyte energy production during ischemia depends upon anaerobic glycolysis inefficiently yielding two ATP per glucose. Substrate augmentation with fructose 1,6-diphosphate (FDP) bypasses the ATP consuming steps of glucokinase and phosphofructokinase thus yielding four ATP per FDP. This study evaluated the impact of FDP administration on myocardial function after acute ischemia.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1443-9506
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pubmed:author |
pubmed-author:AtluriPavanP,
pubmed-author:BerryMark FMF,
pubmed-author:CohenJeffrey EJE,
pubmed-author:GardnerTimothy JTJ,
pubmed-author:GrandTodd JTJ,
pubmed-author:HsuVivian MVM,
pubmed-author:LiaoGeorge PGP,
pubmed-author:PanlilioCorinna MCM,
pubmed-author:SmithMaximillian JMJ,
pubmed-author:SuarezErik EEE,
pubmed-author:SweeneyH LeeHL,
pubmed-author:TaylorMatthew DMD,
pubmed-author:WooY JosephYJ,
pubmed-author:ZentkoSuzanne ESE
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pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
119-23
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:16469539-Adenosine Triphosphate,
pubmed-meshheading:16469539-Animals,
pubmed-meshheading:16469539-Anti-Arrhythmia Agents,
pubmed-meshheading:16469539-Cardiovascular Agents,
pubmed-meshheading:16469539-Fructosediphosphates,
pubmed-meshheading:16469539-Glycolysis,
pubmed-meshheading:16469539-Injections, Intravenous,
pubmed-meshheading:16469539-Male,
pubmed-meshheading:16469539-Models, Animal,
pubmed-meshheading:16469539-Myocardial Ischemia,
pubmed-meshheading:16469539-Myocardial Reperfusion Injury,
pubmed-meshheading:16469539-Phosphofructokinase-1,
pubmed-meshheading:16469539-Rats,
pubmed-meshheading:16469539-Rats, Wistar,
pubmed-meshheading:16469539-Ventricular Dysfunction, Left
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pubmed:year |
2006
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pubmed:articleTitle |
Fructose 1,6-diphosphate administration attenuates post-ischemic ventricular dysfunction.
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pubmed:affiliation |
University of Pennsylvania, School of Medicine, Department of Surgery, Philadelphia, PA 19104, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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