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pubmed:abstractText |
The proximate cause of functional hypothalamic amenorrhea (FHA) is reduced GnRH drive. The concomitant increase in circulating cortisol suggests that psychogenic stress plays an etiologic role, but others have argued for a strictly metabolic cause, such as undernutrition or excessive exercise. Indeed, our finding that the cerebrospinal fluid (CSF) concentration of CRH was not elevated in FHA cast doubt about the extent of hypothalamic-pituitary-adrenal activation in FHA and, therefore, we wondered whether central cortisol levels were elevated.
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pubmed:affiliation |
Department of Gynecology and Obstetrics, Emory University School of Medicine, 1639 Pierce Drive, 4208-WMB, Atlanta, GA 30322, USA.
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