Linked Life Data

1646363

Source:http://linkedlifedata.com/resource/pubmed/id/1646363

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
24
pubmed:dateCreated
1991-7-12
pubmed:abstractText
Diabetes is known to disturb pancreatic glucagon secreting alpha cell function and blood flow control. In a previous study we could show that streptozotocin-induced diabetes suppressed adenosine stimulating effect on glucagon secretion and reduced its vasodilatory properties; since the nucleotide exerts these effects by activation of A2 purinergic receptors known to be positively coupled to adenylate cyclase, we investigated the effect of streptozotocin diabetes on the responses of alpha cells and vascular bed to stimulation of adenylate cyclase through 2 different ways: 1) with isoprenaline by activation of beta adrenergic receptor positively coupled to the enzyme; 2) with forskolin by direct activation of the catalytic unit of adenylate cyclase. In the isolated perfused pancreas of normal rats, isoprenaline (0.01 microM) or forskolin (1 microM) induced a +200 to +300% increase of glucagon secretion and a 20 to 30% increase of pancreatic vascular flow rate. In pancreas of 5-week diabetic rats, alpha cell responses to isoprenaline and forskolin were completely suppressed and the vasodilatory effects of both drugs were significantly reduced (-35 to -50%). Long term in vivo insulin treatment with glycaemia normalization was able to correct both defects. We can conclude that streptozotocin diabetes suppresses glucagon secretion and reduces pancreatic vasodilatation not only in response to activation of receptors positively coupled to adenylate cyclase but also to a direct activation of this enzyme.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0024-3205
pubmed:author
pubmed:issnType
Print
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2349-58
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Diabetes alters the responses of glucagon secreting cells and vascular bed to isoprenaline and forskolin in vitro in rat pancreas.
pubmed:affiliation
Faculté de Médecine, Laboratoire de Pharmacologie, CNRS URA 599, Montpellier, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't