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pubmed-article:16461843pubmed:abstractTextHematopoietic cytokines, granulocyte colony-stimulating factor (G-CSF), and stem cell factor (SCF) were reported to show a neuroprotective effect or to support neurogenesis. These cytokines also mobilize bone marrow (BM) cells into the brain, and the BM-derived cells differentiate into neuronal cells. We administered these hematopoietic cytokines after focal cerebral ischemia and assessed their effects and the therapeutic time window for neuronal regeneration.lld:pubmed
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pubmed-article:16461843pubmed:articleTitleAdministration of hematopoietic cytokines in the subacute phase after cerebral infarction is effective for functional recovery facilitating proliferation of intrinsic neural stem/progenitor cells and transition of bone marrow-derived neuronal cells.lld:pubmed
pubmed-article:16461843pubmed:affiliationDivision of Hematology, Department of Medicine, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan. hkawada@is.icc.u-tokai.ac.jplld:pubmed
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