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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-2-7
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pubmed:abstractText |
Multiple myeloma (MM) is a malignancy characterized by clonal expansion of plasma cells. In 50% of the cases, the neoplastic transformation begins with a chromosomal translocation that juxtaposes the IGH gene locus to an oncogene. Gene copy number changes are also frequent in MM but less characterized than in other neoplasias. We aimed to characterize genes that are amplified and overexpressed in human myeloma cell lines (HMCL) to provide putative molecular targets for MM therapy.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1592-8721
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pubmed:author |
pubmed-author:AlvarezSaraS,
pubmed-author:BlesaDavidD,
pubmed-author:BrievaJose AJA,
pubmed-author:CalasanzMaría JMJ,
pubmed-author:CigudosaJuan CJC,
pubmed-author:DopazoJoaquinJ,
pubmed-author:González-GarcíaInesI,
pubmed-author:LargoCristinaC,
pubmed-author:Martin-SuberoJose IJI,
pubmed-author:SaezBorjaB,
pubmed-author:SiebertReinerR
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pubmed:issnType |
Electronic
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
184-91
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16461302-Caspases,
pubmed-meshheading:16461302-Cell Line, Tumor,
pubmed-meshheading:16461302-Chromosomes, Human,
pubmed-meshheading:16461302-Gene Amplification,
pubmed-meshheading:16461302-Gene Dosage,
pubmed-meshheading:16461302-Gene Expression Profiling,
pubmed-meshheading:16461302-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16461302-Gene Rearrangement,
pubmed-meshheading:16461302-Genes, Neoplasm,
pubmed-meshheading:16461302-Humans,
pubmed-meshheading:16461302-Immunoglobulin Heavy Chains,
pubmed-meshheading:16461302-Lymphoma, B-Cell, Marginal Zone,
pubmed-meshheading:16461302-Multiple Myeloma,
pubmed-meshheading:16461302-Neoplasm Proteins,
pubmed-meshheading:16461302-Proto-Oncogene Proteins c-bcl-2
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pubmed:year |
2006
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pubmed:articleTitle |
Identification of overexpressed genes in frequently gained/amplified chromosome regions in multiple myeloma.
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pubmed:affiliation |
Cytogenetics Unit, Spanish National Cancer Centre, (CNIO), C/ Melchor Fernandez Almagro 3, Madrid, 28029, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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