Linked Life Data

16454172

Source:http://linkedlifedata.com/resource/pubmed/id/16454172

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2006-2-3
pubmed:abstractText
Chaperone-like activity (to trap proteins in biomaterials without their aggregations and to control release of proteins in a native form) is important to design protein delivery systems as well as protein engineering. In general, irreversible adsorption of proteins is unavoidable in trapping them in hydrogel biomaterials because it is difficult to control the mesh size of the hydrogel matrix. We suggested that physically cross-linked nanogels with a size comparable to that of proteins are useful for these purposes. Tailor-made functional nanogels and hydrogels were designed by self-assembly of functional associating polysaccharides such as cholesterol-bearing pullulans. The nanogels can trap hydrophobic molecules, proteins and nucleic acids. They are useful as artificial molecular chaperones and also polymeric nanocarriers in DDS.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0047-1852
pubmed:author
pubmed:issnType
Print
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
215-20
pubmed:dateRevised
2011-7-27
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
[Nanogel engineering and chaperone engineering].
pubmed:affiliation
Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering.
pubmed:publicationType
Journal Article, English Abstract, Review