Linked Life Data

16454170

Source:http://linkedlifedata.com/resource/pubmed/id/16454170

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2006-2-3
pubmed:abstractText
Recently, medical applications of nanotechnology have received much attention. Among them, advances in polymer chemistry have significantly contributed to this field. Here, we review nano-engineering of functional polymers for diagnostic and therapeutic purposes, which have been carried out mainly by our group. Functional polymer-coated nanoparticles can be used for quick detection of biomarkers and DNA separation. Multiarray of hepatocyte spheroids on a microfabricated polymer-brush surface can maintain the hepatocyte viability and liver-specific functions, offering a new high-throughput screening method of pharmacologically and toxicologically active compounds for drug discovery. Polymeric micelles are promising drug carriers, of which the critical parameters such as the size, drug loading and release can be controlled by engineering the constituent block copolymers. Thus, polymeric nano-device will be the leading technology in this field.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0047-1852
pubmed:author
pubmed:issnType
Print
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
199-205
pubmed:dateRevised
2011-7-27
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
[Nano-engineering for biomedical applications].
pubmed:affiliation
Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo.
pubmed:publicationType
Journal Article, English Abstract, Review