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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-2-2
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pubmed:abstractText |
Data from prospective studies suggest a significant reduction in the risk of new diabetes from drug therapies containing angiotensin-converting enzyme (ACE) inhibitors. Since the renin-angiotensin system (RAS) has been found locally in several tissues and cells, including pancreatic islets, we hypothesized that the positive metabolic effects of ACE inhibitors may be due to a beneficial action of these compounds on insulin-secreting beta-cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-nitrotyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin-Converting Enzyme...,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensinogen,
http://linkedlifedata.com/resource/pubmed/chemical/Captopril,
http://linkedlifedata.com/resource/pubmed/chemical/Enalaprilat,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Peptidyl-Dipeptidase A,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Angiotensin, Type 1,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/zofenoprilate
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0804-4643
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
154
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
355-61
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16452552-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:16452552-Angiotensinogen,
pubmed-meshheading:16452552-Captopril,
pubmed-meshheading:16452552-Enalaprilat,
pubmed-meshheading:16452552-Female,
pubmed-meshheading:16452552-Glucose,
pubmed-meshheading:16452552-Humans,
pubmed-meshheading:16452552-Insulin,
pubmed-meshheading:16452552-Islets of Langerhans,
pubmed-meshheading:16452552-Male,
pubmed-meshheading:16452552-Middle Aged,
pubmed-meshheading:16452552-Oxidative Stress,
pubmed-meshheading:16452552-Peptidyl-Dipeptidase A,
pubmed-meshheading:16452552-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:16452552-RNA,
pubmed-meshheading:16452552-Receptor, Angiotensin, Type 1,
pubmed-meshheading:16452552-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16452552-Tyrosine
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pubmed:year |
2006
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pubmed:articleTitle |
The direct effects of the angiotensin-converting enzyme inhibitors, zofenoprilat and enalaprilat, on isolated human pancreatic islets.
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pubmed:affiliation |
Metabolic Unit, Department of Endocrinology and Metabolism, University of Pisa, Ospedale Cisanello, via Paradisa 2, 56100 Pisa, Italy.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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