|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1992-9-8
|
|
pubmed:abstractText |
The relative efficacies of cilofungin, amphotericin B and fluconazole were compared in the treatment of systemic Candida albicans infection in neutropenic mice. Thirty-one day survival rates were lowest for cilofungin (14.6%), intermediate for amphotericin B (37.6%) and highest for fluconazole (50.5%). Residual tissue infection in surviving animals was observed with all agents, but was heaviest with fluconazole, especially in the kidneys.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0300-8126
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
20
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
168-70
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:1644494-Amphotericin B,
pubmed-meshheading:1644494-Animals,
pubmed-meshheading:1644494-Antifungal Agents,
pubmed-meshheading:1644494-Candidiasis,
pubmed-meshheading:1644494-Colony Count, Microbial,
pubmed-meshheading:1644494-Disease Models, Animal,
pubmed-meshheading:1644494-Drug Evaluation, Preclinical,
pubmed-meshheading:1644494-Echinocandins,
pubmed-meshheading:1644494-Female,
pubmed-meshheading:1644494-Fluconazole,
pubmed-meshheading:1644494-Fungemia,
pubmed-meshheading:1644494-Kidney,
pubmed-meshheading:1644494-Liver,
pubmed-meshheading:1644494-Lung,
pubmed-meshheading:1644494-Mice,
pubmed-meshheading:1644494-Neutropenia,
pubmed-meshheading:1644494-Peptides,
pubmed-meshheading:1644494-Peptides, Cyclic,
pubmed-meshheading:1644494-Spleen,
pubmed-meshheading:1644494-Survival Rate
|
|
pubmed:articleTitle |
Comparison of the efficacy of cilofungin, fluconazole and amphotericin B in the treatment of systemic Candida albicans infection in the neutropenic mouse.
|
|
pubmed:affiliation |
Dept. of Microbiology, St. Micheal's Hospital, Toronto, Canada.
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|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
