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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2006-3-8
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pubmed:abstractText |
Telomerase activation, which is observed in most human cancers, plays an important role in carcinogenesis. Human telomerase reverse transcriptase (hTERT) is a subunit of telomerase that is essential for telomerase activity. The aim of the study was to investigate whether nonsteroidal antiinflammatory drugs (NSAIDs) inhibit telomerase activity and hTERT.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-(5-(4-chlorophenyl)-3-(trifluorome...,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Aspirin,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Indomethacin,
http://linkedlifedata.com/resource/pubmed/chemical/Luciferases,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/Telomerase
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0008-543X
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pubmed:author |
pubmed-author:CaseN BNB,
pubmed-author:ChanAnnie O OAO,
pubmed-author:HeHuaH,
pubmed-author:KungHsiang FuHF,
pubmed-author:LamShiu KumSK,
pubmed-author:LinMarie C MMC,
pubmed-author:RIBIAA,
pubmed-author:WangJi DeJD,
pubmed-author:WongBenjamin Chun-YuBC,
pubmed-author:XiaHarry Hua-XiangHH,
pubmed-author:YuenMan FungMF
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pubmed:copyrightInfo |
(c) 2006 American Cancer Society.
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1243-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16444744-Adenocarcinoma,
pubmed-meshheading:16444744-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:16444744-Aspirin,
pubmed-meshheading:16444744-Blotting, Western,
pubmed-meshheading:16444744-Colonic Neoplasms,
pubmed-meshheading:16444744-Cyclooxygenase 2,
pubmed-meshheading:16444744-Cyclooxygenase Inhibitors,
pubmed-meshheading:16444744-DNA-Binding Proteins,
pubmed-meshheading:16444744-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16444744-Humans,
pubmed-meshheading:16444744-Indomethacin,
pubmed-meshheading:16444744-Luciferases,
pubmed-meshheading:16444744-Promoter Regions, Genetic,
pubmed-meshheading:16444744-Pyrazoles,
pubmed-meshheading:16444744-RNA, Messenger,
pubmed-meshheading:16444744-RNA, Neoplasm,
pubmed-meshheading:16444744-Response Elements,
pubmed-meshheading:16444744-Sulfonamides,
pubmed-meshheading:16444744-Telomerase,
pubmed-meshheading:16444744-Transcription, Genetic,
pubmed-meshheading:16444744-Tumor Cells, Cultured
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pubmed:year |
2006
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pubmed:articleTitle |
Inhibition of human telomerase reverse transcriptase by nonsteroidal antiinflammatory drugs in colon carcinoma.
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pubmed:affiliation |
Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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