Source:http://linkedlifedata.com/resource/pubmed/id/16441067
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
2006-1-30
|
pubmed:abstractText |
Five new 14,15-secopregnane derivatives, named argelosides K-O (1-5), have been isolated from Solenostemma argel leaves. Their structures were established by a detailed spectroscopic analysis. In particular, argeloside N (1) showed in the sugar portion an unusual 3-O-methyl-2,6-dideoxyhexopyranose unit characterized by the occurrence of a Delta3 double bond, and argeloside O (5) displayed an unusual moiety linked to position 3 probably derived by the oxidation of a 3-O-methyl-2,6-dideoxyhexopyranose unit. The propensity of compounds 2, 3, and 5 and argeloside F (6) to inhibit TNF-alpha release by LPS-stimulated RAW 264.7 mouse cells was evaluated.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0163-3864
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
69
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
50-4
|
pubmed:meshHeading |
pubmed-meshheading:16441067-Animals,
pubmed-meshheading:16441067-Asclepiadaceae,
pubmed-meshheading:16441067-Egypt,
pubmed-meshheading:16441067-Lipopolysaccharides,
pubmed-meshheading:16441067-Macrophages,
pubmed-meshheading:16441067-Mice,
pubmed-meshheading:16441067-Molecular Structure,
pubmed-meshheading:16441067-Nuclear Magnetic Resonance, Biomolecular,
pubmed-meshheading:16441067-Plant Leaves,
pubmed-meshheading:16441067-Plants, Medicinal,
pubmed-meshheading:16441067-Pregnanes,
pubmed-meshheading:16441067-Structure-Activity Relationship,
pubmed-meshheading:16441067-Tumor Necrosis Factor-alpha
|
pubmed:year |
2006
|
pubmed:articleTitle |
14,15-secopregnane derivatives from the leaves of Solenostemma argel.
|
pubmed:affiliation |
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Salerno, Italy.
|
pubmed:publicationType |
Journal Article
|