Linked Life Data

16440149

Source:http://linkedlifedata.com/resource/pubmed/id/16440149

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-1-27
pubmed:abstractText
Compared to chronic hypertension, little is known about the pathophysiology of acute hypertension and its recovery. To characterize this, we investigated the functional and structural properties of the common carotid arteries (CCA) from 35 rats. We established a unilateral and reversible carotid arterial hypertension model using the partial transverse aortic constriction (TAC) technique. By TAC, the right CCAs were made to endure a pressure-overload environment, while the left CCAs remained under normotension. The TACs were removed 2 weeks later, which unloaded the hypertensive effects. We compared the contractile, histological, and molecular responses of the CCA before TAC, during TAC (the hypertension period), and after removal of TAC (the recovery period). Vessel contractility was nearly abolished during 2 weeks of TAC. The recovery process from hypertension showed an initial hypercontractile period within a week. The relaxation response due to acetylcholine, as measured during the recovery period, showed a longer time course than the contractility for recovering its magnitude. During the hypertension period, the media thickness increased and this persisted throughout the recovery period. Apoptosis of the endothelial layer was significantly increased during the hypertension period and this disappeared 2 weeks after recovery. Expression of endothelial NO synthase was not detectable at the end of the hypertension period, but this gradually returned to the basal level after 2 weeks of recovery. Although increased contractility is usually expected in chronic hypertensive vessels, an abrupt pressure overload decreases contractility and the endothelium-dependent relaxation. It also increases endothelial apoptosis and the media thickness. These findings have clinical relevance, and they could be applied to human acute and severe hypertension and its recovery.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0910-8327
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
48-55
pubmed:meshHeading
pubmed-meshheading:16440149-Acetylcholine, pubmed-meshheading:16440149-Animals, pubmed-meshheading:16440149-Apoptosis, pubmed-meshheading:16440149-Blood Pressure, pubmed-meshheading:16440149-Blotting, Western, pubmed-meshheading:16440149-Carotid Artery, Common, pubmed-meshheading:16440149-Disease Models, Animal, pubmed-meshheading:16440149-Endothelium, Vascular, pubmed-meshheading:16440149-Hypertension, pubmed-meshheading:16440149-Immunohistochemistry, pubmed-meshheading:16440149-Male, pubmed-meshheading:16440149-Nitric Oxide Synthase Type III, pubmed-meshheading:16440149-Potassium Chloride, pubmed-meshheading:16440149-Rats, pubmed-meshheading:16440149-Rats, Sprague-Dawley, pubmed-meshheading:16440149-Recovery of Function, pubmed-meshheading:16440149-Serotonin Agents, pubmed-meshheading:16440149-Time Factors, pubmed-meshheading:16440149-Tunica Media, pubmed-meshheading:16440149-Vascular Resistance, pubmed-meshheading:16440149-Vasoconstriction, pubmed-meshheading:16440149-Vasodilation, pubmed-meshheading:16440149-Vasodilator Agents
pubmed:year
2006
pubmed:articleTitle
Effect of pressure overload and its recovery on the rat carotid artery: change of vascular reactivity and remodeling process.
pubmed:affiliation
Department of Internal Medicine, Chungbuk National University Hospital, 62 Gaeshin-Dong, Heungduk-Gu, Cheongju, South Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't