Source:http://linkedlifedata.com/resource/pubmed/id/16439118
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2006-2-7
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| pubmed:abstractText |
Fullerene was entrapped in polyvinylpyrrolidone of 60-80 kDa at a molar ratio range of 0.42-0.67:1, resulting in a water-soluble derivative with a mean particle diameter of about 688 nm, named "Radical Sponge" because of its ROS-scavenging ability as previously demonstrated, and examined in the present study for its photo-biological actions toward human skin keratinocytes HaCaT. The keratinocytes were repeatedly irradiated with a visible light of wavelengths of 400-2000 nm (approximately 19,800 lux) in the presence or absence of Radical Sponge of 25-75 microM and did not exhibit any photo-cytotoxicity due to coexistent Radical Sponge as compared with the sham-irradiation control. Radical Sponge exerted a more marked cytoprotection at doses of 10-40 microM against UVA irradiation of 30 J/cm(2) when it was pre-irradiationally administered and rinsed out immediately before the irradiation, than when administered only during or after the irradiation, indicating the preventive rather than therapeutic or ray-sheltering effect of Radical Sponge on UVA injuries. Cytoprotection by Radical Sponge against UVA was achieved at the advisable range doses of 10-40 microM in contrast to no effect of polyvinylpyrrolidone alone; its dose-dependency was advantageous over that of VC-IP, a tetra-alkyl-esterized provitamin C, which became less cytoprotective above 20 microM. Thus, Radical Sponge is expected as an anti-UVA-preventive agent without visible-light-catalyzed cytotoxicity toward human skin keratinocytes.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0960-894X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
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| pubmed:volume |
16
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1590-5
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| pubmed:meshHeading |
pubmed-meshheading:16439118-Cytoprotection,
pubmed-meshheading:16439118-Fullerenes,
pubmed-meshheading:16439118-Humans,
pubmed-meshheading:16439118-Keratinocytes,
pubmed-meshheading:16439118-Light,
pubmed-meshheading:16439118-Skin,
pubmed-meshheading:16439118-Solubility,
pubmed-meshheading:16439118-Ultraviolet Rays,
pubmed-meshheading:16439118-Water
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
The water-soluble fullerene derivative "Radical Sponge" exerts cytoprotective action against UVA irradiation but not visible-light-catalyzed cytotoxicity in human skin keratinocytes.
|
| pubmed:affiliation |
Laboratory of Cell-Death Control BioTechnology, Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima, Shobara, Hiroshima 727-0023, Japan.
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| pubmed:publicationType |
Journal Article
|